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<p>Nanoscale materials can improve cancer treatment by safely and efficiently delivering chemotherapeutic drugs. This study was designated to load the anticancer drug doxorubicin (DOX) into chitosan-coated Pb2Mn2Fe12O22 magnetic nanoparticles (CT-MNPs) and compare their physicochemical and biological effects with free drug, in addition to the therapeutic role of DOX-CT-MNPs to acting efficaciously in restraint of cancer cells growth and evolution using Ehrlich solid tumor model (EST). Forty female mice were randomly and equally split into four groups (EST; EST + Free DOX; EST + CT-MNPs; and EST + DOX-CT-MNPs). Our findings show that treating EST with DOX, either free or loaded on CT-MNPs, inhibits tumour growth by producing oxidative stress, disrupting the antioxidant system, activating apoptosis, and arresting the cell cycle. Furthermore, DOX loaded on CT-MNPs had greater anticancer activity than DOX in its free form. This highlights the potential advantages of CT-MNPs in tumour therapy and drug delivery.</p>

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In vivo antitumor activity of doxorubicin loaded on chitosan functionalized Pb2Mn2Fe12O22 magnetic nanoparticles

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月2日

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  • Aliaa M. Radwan,
  • Afaf El-Atrash,
  • Maha Elkholy,
  • Nagat Fawzy Nawar,
  • Ehab Tousson,
  • Amina I. Ghoneim

摘要

Nanoscale materials can improve cancer treatment by safely and efficiently delivering chemotherapeutic drugs. This study was designated to load the anticancer drug doxorubicin (DOX) into chitosan-coated Pb2Mn2Fe12O22 magnetic nanoparticles (CT-MNPs) and compare their physicochemical and biological effects with free drug, in addition to the therapeutic role of DOX-CT-MNPs to acting efficaciously in restraint of cancer cells growth and evolution using Ehrlich solid tumor model (EST). Forty female mice were randomly and equally split into four groups (EST; EST + Free DOX; EST + CT-MNPs; and EST + DOX-CT-MNPs). Our findings show that treating EST with DOX, either free or loaded on CT-MNPs, inhibits tumour growth by producing oxidative stress, disrupting the antioxidant system, activating apoptosis, and arresting the cell cycle. Furthermore, DOX loaded on CT-MNPs had greater anticancer activity than DOX in its free form. This highlights the potential advantages of CT-MNPs in tumour therapy and drug delivery.