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<p> Vitamin A (VA) supplementation has been recommended for pregnant women at-risk of deficiency, and is widely applied to children under 5 in developing countries. We addressed the effect of excessive VA exposure during pregnancy, lactation and first weeks of life on VA, vitamin E and lipid metabolism in rat offspring. Sprague-Dawley female rats were fed either a 2300 IU.kg<sup>−1</sup> VA diet (control diet) or a 9858 IU.kg<sup>−1</sup> VA diet (vitamin A supplemented diet – VAS diet) and mated with males fed the control diet. Weanlings were fed the same diet as their mothers until they were 8 weeks old. Organs and adipose tissue were collected from half of the offspring after fasting. The other half was force-fed an oil-in-water emulsion containing retinyl palmitate and [1,1,1-<sup>13</sup>C<sub>3</sub>]triolein. VAS-fed female and male offspring displayed a significant accumulation of VA in the liver (18 and 32 times more retinyl esters than respective controls, <i>p</i> &lt; 0.0001) and VAS-fed males exhibited higher plasma retinol concentrations (+ 42.8 ± 6.6% compared to control males, <i>p</i> = 0.0011). Fasting plasma triglyceride concentration was higher for both VAS-fed females and males (+ 44.6 ± 6.8%, <i>p</i> = 0.0007 and + 58.8 ± 20.2%, <i>p</i> = 0.0343, compared to their respective controls). Lipid absorption was increased in VAS-fed males (+ 60.9% of [1-<sup>13</sup>&#xa0;C]oleate absorption at 1.5&#xa0;h post-gavage, <i>p</i> &lt; 0.0001). Overall, our data show that VA overexposure disbalances VA status and detrimentally impacts lipid metabolism in offspring.</p>

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Perinatal vitamin A excess impacts vitamin A and lipid metabolism in rat offspring

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月7日

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  • Angélique Berthomé,
  • Tiffany Antoine,
  • Laure Meiller,
  • Roland Govers,
  • Philippe Guichard,
  • Charlotte Sabran,
  • Teresa Gonzalez,
  • Marion Nowicki,
  • Claire Bordat,
  • Patrick Borel,
  • Michel Grino,
  • Valérie Sauvinet,
  • Emmanuelle Reboul

摘要

Vitamin A (VA) supplementation has been recommended for pregnant women at-risk of deficiency, and is widely applied to children under 5 in developing countries. We addressed the effect of excessive VA exposure during pregnancy, lactation and first weeks of life on VA, vitamin E and lipid metabolism in rat offspring. Sprague-Dawley female rats were fed either a 2300 IU.kg−1 VA diet (control diet) or a 9858 IU.kg−1 VA diet (vitamin A supplemented diet – VAS diet) and mated with males fed the control diet. Weanlings were fed the same diet as their mothers until they were 8 weeks old. Organs and adipose tissue were collected from half of the offspring after fasting. The other half was force-fed an oil-in-water emulsion containing retinyl palmitate and [1,1,1-13C3]triolein. VAS-fed female and male offspring displayed a significant accumulation of VA in the liver (18 and 32 times more retinyl esters than respective controls, p < 0.0001) and VAS-fed males exhibited higher plasma retinol concentrations (+ 42.8 ± 6.6% compared to control males, p = 0.0011). Fasting plasma triglyceride concentration was higher for both VAS-fed females and males (+ 44.6 ± 6.8%, p = 0.0007 and + 58.8 ± 20.2%, p = 0.0343, compared to their respective controls). Lipid absorption was increased in VAS-fed males (+ 60.9% of [1-13 C]oleate absorption at 1.5 h post-gavage, p < 0.0001). Overall, our data show that VA overexposure disbalances VA status and detrimentally impacts lipid metabolism in offspring.