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<p>Phototherapy, distinguished by its exceptional selectivity, noninvasive nature, and negligible drug resistance, has emerged as a promising antibiotic-free antimicrobial approach. However, the therapeutic efficacy of organic photosensitizers (PSs), particularly porphyrin-based systems, is significantly limited by strong π-π stacking-induced self-aggregation, an inherent challenge arising from their extended conjugated structures. To address this limitation, we developed a spatial three-dimensional (3D) multiple-twisted strategy to mitigate photoactivity quenching in porphyrin-based PSs. Leveraging this approach, we designed Crown-TTEP, a crown-ether-based porous organic polymer (POP) with imidazole linkages, synthesized via polymerization of twisted tetra-1,4-di(4-aldehyde phenyl)phenyl-porphyrin (TTEP) and crown-shaped crown ether. This unique architecture enables synergistic crown/photothermal/photodynamic therapy (PTT/PDT). The multiple-twisted 3D structure of Crown-TTEP effectively suppresses aggregation-induced quenching, significantly enhancing photosensitizing activity. In vitro and in vivo studies confirmed broad-spectrum antimicrobial efficacy of Crown-TTEP, demonstrating outstanding additive antibacterial activity against ​​Gram-positive (G<sup>+</sup>) and Gram-negative (G<sup>−</sup>) pathogens under NIR irradiation. The synergistic interplay of PTT/PDT and the crown skeleton not only ensures potent bactericidal effects but also accelerates the healing of infected wounds. This work establishes a design paradigm for enhancing the phototherapeutic performance of POP-based antimicrobial agents, offering a promising strategy for next-generation antibacterial treatments.</p>

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Spatial multiple distortion as a facile strategy boosting the efficacy of photothermal and photodynamic therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Jiawen Jiang,
  • Haoshu Xu,
  • Wenjing Li,
  • Lan Chen,
  • Shengjun Ma,
  • Chunzhen Zhao,
  • Jibin Wang,
  • Bin Wang,
  • Long Wang

摘要

Phototherapy, distinguished by its exceptional selectivity, noninvasive nature, and negligible drug resistance, has emerged as a promising antibiotic-free antimicrobial approach. However, the therapeutic efficacy of organic photosensitizers (PSs), particularly porphyrin-based systems, is significantly limited by strong π-π stacking-induced self-aggregation, an inherent challenge arising from their extended conjugated structures. To address this limitation, we developed a spatial three-dimensional (3D) multiple-twisted strategy to mitigate photoactivity quenching in porphyrin-based PSs. Leveraging this approach, we designed Crown-TTEP, a crown-ether-based porous organic polymer (POP) with imidazole linkages, synthesized via polymerization of twisted tetra-1,4-di(4-aldehyde phenyl)phenyl-porphyrin (TTEP) and crown-shaped crown ether. This unique architecture enables synergistic crown/photothermal/photodynamic therapy (PTT/PDT). The multiple-twisted 3D structure of Crown-TTEP effectively suppresses aggregation-induced quenching, significantly enhancing photosensitizing activity. In vitro and in vivo studies confirmed broad-spectrum antimicrobial efficacy of Crown-TTEP, demonstrating outstanding additive antibacterial activity against ​​Gram-positive (G+) and Gram-negative (G−) pathogens under NIR irradiation. The synergistic interplay of PTT/PDT and the crown skeleton not only ensures potent bactericidal effects but also accelerates the healing of infected wounds. This work establishes a design paradigm for enhancing the phototherapeutic performance of POP-based antimicrobial agents, offering a promising strategy for next-generation antibacterial treatments.