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<p>Ovarian tissue cryopreservation followed by transplantation may damage the ovaries, potentially impeding fertility restoration. The notable antioxidant properties of curcumin highlight its potential as a therapeutic agent for enhancing fertility restoration. The use of nano-curcumin to improve ovarian tissue transplantation outcomes after vitrification for fertility preservation remains unknown. This study aimed to evaluate endocrine function, by measuring estradiol (E2), follicle-stimulating hormone (FSH), and anti-Müllerian hormone (AMH), and ovarian follicle count in rats subjected to vitrification and transplantation. Thirty female rats were categorized into three groups (<i>n</i> = 10/group): control (Group 1), untreated (Group 2), and nano-curcumin treated (Group 3; 2&#xa0;mg/kg/day for 14 days). The rats were euthanized, and blood samples and ovaries were collected for analysis. The FSH level in the treated group (0.99 (0.97-1.00) mIU/ml) was significantly lower compared to that in the other groups, with a significant difference, particularly against Group 2 (<i>p</i> &lt; 0.05). E2 and AMH values were higher in the treated group, with increased primordial and total follicle counts, though not statistically significant (<i>p</i> = 0.069 and <i>p</i> = 0.051). The administration of nano-curcumin may improve hormonal function and increase the number of follicles in rat ovaries after vitrification and transplantation.</p>

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Nano-curcumin potentially ameliorates hormonal function and follicular counts following the vitrification and transplantation of rat ovarian tissue

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月3日

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  • Hendy Hendarto,
  • Satria Audi Hutama,
  • Relly Yanuari Primariawan,
  • Firas Farisi Alkaff,
  • Bambang Satrio Utomo,
  • Widjiati Widjiati,
  • Nao Suzuki

摘要

Ovarian tissue cryopreservation followed by transplantation may damage the ovaries, potentially impeding fertility restoration. The notable antioxidant properties of curcumin highlight its potential as a therapeutic agent for enhancing fertility restoration. The use of nano-curcumin to improve ovarian tissue transplantation outcomes after vitrification for fertility preservation remains unknown. This study aimed to evaluate endocrine function, by measuring estradiol (E2), follicle-stimulating hormone (FSH), and anti-Müllerian hormone (AMH), and ovarian follicle count in rats subjected to vitrification and transplantation. Thirty female rats were categorized into three groups (n = 10/group): control (Group 1), untreated (Group 2), and nano-curcumin treated (Group 3; 2 mg/kg/day for 14 days). The rats were euthanized, and blood samples and ovaries were collected for analysis. The FSH level in the treated group (0.99 (0.97-1.00) mIU/ml) was significantly lower compared to that in the other groups, with a significant difference, particularly against Group 2 (p < 0.05). E2 and AMH values were higher in the treated group, with increased primordial and total follicle counts, though not statistically significant (p = 0.069 and p = 0.051). The administration of nano-curcumin may improve hormonal function and increase the number of follicles in rat ovaries after vitrification and transplantation.