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<p>This study investigated the effects of oral multivitamin supplementation on vitamin levels in Chinese gastric cancer patients after gastrectomy, aiming to provide a basis for postoperative vitamin supplementation strategies. A total of 78 patients who underwent radical gastrectomy were divided into an experimental group (41 patients, receiving oral multivitamins) and a control group (37 patients). Levels of folic acid, vitamin B<sub>12</sub>, vitamin B<sub>1</sub>, and 25-hydroxyvitamin D were compared before and one month after surgery. Results showed that the level of vitamin B<sub>1</sub> in the experimental group was substantially higher than that in the control group when comparing the difference value between the preoperative and 1-month postoperative periods (<i>P</i> &lt; 0.05). Although the deficiency rates of 25-hydroxyvitamin D and vitamin B<sub>1</sub> were relatively high in both groups, the vitamin B<sub>1</sub> deficiency rates of the experimental group 1 month postoperatively were significantly lower than preoperative rates (<i>P</i> &lt; 0.05). Subgroup analysis revealed that partial gastrectomy patients in the experimental group had increased vitamin B<sub>1</sub> levels and decreased deficiency rates compared to the control group (<i>P</i> &lt; 0.05). The study suggests that systematic multivitamin supplementation should be routinely administered to Chinese gastric cancer patients following gastrectomy, with particular emphasis on initiating vitamin B<sub>1</sub> and vitamin D supplementation upon resumption of semi-solid oral intake. Patients after total gastrectomy may require additional vitamin B<sub>1</sub> supplementation. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.</p>

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The strategy of vitamin supplementation in Chinese patients with gastric cancer after gastrectomy: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Depin Li,
  • Mingdi Zhao,
  • Xiaoliang Cheng,
  • Zhisong Tao,
  • Yuxing You,
  • Yangyang Fu,
  • Tingwen Wang,
  • Jiaqing Huang,
  • Xin Li,
  • Xiaojie Bian,
  • Wenxian Guan

摘要

This study investigated the effects of oral multivitamin supplementation on vitamin levels in Chinese gastric cancer patients after gastrectomy, aiming to provide a basis for postoperative vitamin supplementation strategies. A total of 78 patients who underwent radical gastrectomy were divided into an experimental group (41 patients, receiving oral multivitamins) and a control group (37 patients). Levels of folic acid, vitamin B12, vitamin B1, and 25-hydroxyvitamin D were compared before and one month after surgery. Results showed that the level of vitamin B1 in the experimental group was substantially higher than that in the control group when comparing the difference value between the preoperative and 1-month postoperative periods (P < 0.05). Although the deficiency rates of 25-hydroxyvitamin D and vitamin B1 were relatively high in both groups, the vitamin B1 deficiency rates of the experimental group 1 month postoperatively were significantly lower than preoperative rates (P < 0.05). Subgroup analysis revealed that partial gastrectomy patients in the experimental group had increased vitamin B1 levels and decreased deficiency rates compared to the control group (P < 0.05). The study suggests that systematic multivitamin supplementation should be routinely administered to Chinese gastric cancer patients following gastrectomy, with particular emphasis on initiating vitamin B1 and vitamin D supplementation upon resumption of semi-solid oral intake. Patients after total gastrectomy may require additional vitamin B1 supplementation. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.