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<p>The triglyceride-glucose (TyG) index represents a pioneering approach to assessing insulin resistance. The objective of this study was to investigate the potential association between the TyG index and muscle strength in a Chinese middle-aged and older adults without comorbid chronic diseases. A total of 2,086 participants were identified in the China Health and Retirement Longitudinal Study (CHARLS). Muscle strength was assessed using two methods: absolute handgrip strength (HGS) and relative HGS, which was normalised by body weight or BMI. To evaluate the correlation between the TyG index and muscle strength, a range of analytical techniques was employed, including linear regression models, logistic regression models, and restricted cubic spline (RCS) analyses. A reduction in relative HGS was observed in the high TyG population compared to the low TyG population, whereas no such reduction was observed for absolute HGS. Regression analyses revealed a significant negative correlation between TyG and relative HGS, after controlling for a range of potential confounding variables. Conversely, no such relationship was observed between TyG and absolute HGS. The RCS results indicated that no nonlinear relationship existed between TyG and absolute HGS. In Chinese middle-aged and older adults, a negative correlation was observed between the TyG index and relative HGS, but not absolute HGS, in individuals without comorbid chronic diseases.</p>

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Relationship between triglyceride-glucose index and muscle strength in middle-aged and older Chinese adults without chronic diseases: a nationwide longitudinal cohort study

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  • 出版模式：

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  • 发表日期：

    2026年6月27日

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  • Xiaoyu Pan,
  • Xing Zhong,
  • Ajuan Gong,
  • Xiaomin Huang,
  • Tianrong Pan

摘要

The triglyceride-glucose (TyG) index represents a pioneering approach to assessing insulin resistance. The objective of this study was to investigate the potential association between the TyG index and muscle strength in a Chinese middle-aged and older adults without comorbid chronic diseases. A total of 2,086 participants were identified in the China Health and Retirement Longitudinal Study (CHARLS). Muscle strength was assessed using two methods: absolute handgrip strength (HGS) and relative HGS, which was normalised by body weight or BMI. To evaluate the correlation between the TyG index and muscle strength, a range of analytical techniques was employed, including linear regression models, logistic regression models, and restricted cubic spline (RCS) analyses. A reduction in relative HGS was observed in the high TyG population compared to the low TyG population, whereas no such reduction was observed for absolute HGS. Regression analyses revealed a significant negative correlation between TyG and relative HGS, after controlling for a range of potential confounding variables. Conversely, no such relationship was observed between TyG and absolute HGS. The RCS results indicated that no nonlinear relationship existed between TyG and absolute HGS. In Chinese middle-aged and older adults, a negative correlation was observed between the TyG index and relative HGS, but not absolute HGS, in individuals without comorbid chronic diseases.