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<p>Fetal radiation exposure can cause pregnancy loss, malformation, growth disturbance, and mutagenic/carcinogenic effects. Insufficient guidance on radiation protection for women of childbearing age complicates risk assessment. This population-based retrospective cohort study investigated preconception CT radiation on stillbirths using Taiwan National Health Insurance Database from 1995 to 2018. A total of 1,218,744 births (live and stillbirth) of 940,280 women were eligible, including 1,179,443 live births of 913,811 women in the control group and 13,631 stillbirths(≥ 20 weeks of gestation or weight ≥ 500&#xa0;g) of 13,046 women in the study group. CT exposure within 90 days, 1 year, 3 years, and 5 years before conception occurred in 0.6%, 2.5%, 6.1%, and 9.0% of stillbirth mothers, versus 0.5%, 2.1%, 5.4%, and 8.1% of controls. In adjusted analyses, CT exposure within 1 year (aOR = 1.14; 95% CI: 1.01–1.28; <i>p</i> = 0.0325) and 3 years (aOR = 1.08; 95% CI: 1.00–1.17; <i>p</i> = 0.0482) before pregnancy was modestly associated with stillbirth, while the 90-day (aOR = 1.12; 95% CI: 0.88–1.42; <i>p</i> = 0.355) and 5-year (aOR = 1.06; 95% CI: 0.99–1.13; <i>p</i> = 0.0917) windows were not significant. These small effect sizes, together with potential residual confounding and lack of consistent dose–response, suggest that any true association between preconception CT radiation and stillbirth is weak. Further research with detailed dose assessment and indication data is warranted.</p>

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Preconception computed tomography exposure and risk of stillbirth in a nationwide population based cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月25日

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  • I-Gung Li,
  • Yao-Hsu Yang,
  • Chuan-Pin Lee,
  • Ko-Jung Chen,
  • Sheng-Wei Chang,
  • Yu-Li Lee,
  • Ming-De Huang,
  • Yuan-Hsiung Tsai

摘要

Fetal radiation exposure can cause pregnancy loss, malformation, growth disturbance, and mutagenic/carcinogenic effects. Insufficient guidance on radiation protection for women of childbearing age complicates risk assessment. This population-based retrospective cohort study investigated preconception CT radiation on stillbirths using Taiwan National Health Insurance Database from 1995 to 2018. A total of 1,218,744 births (live and stillbirth) of 940,280 women were eligible, including 1,179,443 live births of 913,811 women in the control group and 13,631 stillbirths(≥ 20 weeks of gestation or weight ≥ 500 g) of 13,046 women in the study group. CT exposure within 90 days, 1 year, 3 years, and 5 years before conception occurred in 0.6%, 2.5%, 6.1%, and 9.0% of stillbirth mothers, versus 0.5%, 2.1%, 5.4%, and 8.1% of controls. In adjusted analyses, CT exposure within 1 year (aOR = 1.14; 95% CI: 1.01–1.28; p = 0.0325) and 3 years (aOR = 1.08; 95% CI: 1.00–1.17; p = 0.0482) before pregnancy was modestly associated with stillbirth, while the 90-day (aOR = 1.12; 95% CI: 0.88–1.42; p = 0.355) and 5-year (aOR = 1.06; 95% CI: 0.99–1.13; p = 0.0917) windows were not significant. These small effect sizes, together with potential residual confounding and lack of consistent dose–response, suggest that any true association between preconception CT radiation and stillbirth is weak. Further research with detailed dose assessment and indication data is warranted.