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<p>This study determined the complete genomic sequence of the viral hemorrhagic septicemia virus (VHSV) strain GY-2307 isolated form farmed <i>paralichthys olivaceus</i> in northeast China. The whole genome length of GY-2307 comprised 11,140 nucleotides (nt), and the overall organization was typical of that observed for all other VHSV strains. The phylogenetic analysis results indicated that the GY-2307 isolate belonged to genotype Ⅳa and significantly related to other Korean and Japanese isolates. The N, P, M, NV and L genes of GY-2307 were compared with the VHSV sequences in GenBank. The results revealed that 315 nt were substituted, 71 of which exhibited amino acid change in the GY-2307 genome. In the G gene, specific nucleotides and amino acid variations of the Chinese isolates of VHSV were observed when compared with 28 isolates from other counties. Of the 23 nucleotide sites that changed, 9 resulted in amino acid substitution. The data further indicated that the genotype Ⅳa VHSV was introduced to and evolved in <i>paralichthys olivaceus</i> farm environments in China.</p>

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Genome analysis of viral hemorrhagic septicemia virus isolated from Paralichthys olivaceus in China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月26日

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  • Ye Xu,
  • Taishan Tang,
  • Na Wang,
  • Chao Ding,
  • Yi Zhou,
  • Fengzhi Wang,
  • Hongan Duan

摘要

This study determined the complete genomic sequence of the viral hemorrhagic septicemia virus (VHSV) strain GY-2307 isolated form farmed paralichthys olivaceus in northeast China. The whole genome length of GY-2307 comprised 11,140 nucleotides (nt), and the overall organization was typical of that observed for all other VHSV strains. The phylogenetic analysis results indicated that the GY-2307 isolate belonged to genotype Ⅳa and significantly related to other Korean and Japanese isolates. The N, P, M, NV and L genes of GY-2307 were compared with the VHSV sequences in GenBank. The results revealed that 315 nt were substituted, 71 of which exhibited amino acid change in the GY-2307 genome. In the G gene, specific nucleotides and amino acid variations of the Chinese isolates of VHSV were observed when compared with 28 isolates from other counties. Of the 23 nucleotide sites that changed, 9 resulted in amino acid substitution. The data further indicated that the genotype Ⅳa VHSV was introduced to and evolved in paralichthys olivaceus farm environments in China.