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<p>Accurate assessment of lymph node (LN) status is critical in cancer management, particularly in gynecological malignancies. However, preoperative identification of pathological LNs remains a significant challenge with current imaging modalities. Full-field optical coherence tomography (FF-OCT) is a non-invasive microscopic technique based on tissue reflectivity and light interference, providing real-time, high-resolution images in &lt; 10&#xa0;min, with no tissue preparation or alteration required. Our aim was to evaluate the diagnostic accuracy of FF-OCT in identifying LN metastatic foci measuring ≥ 0.2&#xa0;mm in gynecological cancers, in an intraoperative setting. Comparative analysis of 80 fresh ex vivo LNs with FF-OCT versus gold standard pathology showed high accuracy (97.6%), sensitivity (92.3%), and specificity (98.2%) of FF-OCT. These results support the suitability of FF-OCT integration into clinical practice for real-time assessment of LN status, thereby improving intraoperative decision making while enabling subsequent routine histological analysis.</p>

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Microscopic assessment of lymph node status in gynecological malignancies using full-field optical coherence tomography

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月21日

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  • Matteo Pavone,
  • Laetitia Rebiere,
  • Lise Lecointre,
  • Emma Carles,
  • Clément Tondon,
  • Pauline Le Van Quyen,
  • Barbara Seeliger,
  • Diana Giannarelli,
  • Thomas Lampert,
  • Nicolò Bizzarri,
  • Giovanni Scambia,
  • Cherif Akladios,
  • Alina Nicolae,
  • Denis Querleu,
  • Aïna Venkatasamy

摘要

Accurate assessment of lymph node (LN) status is critical in cancer management, particularly in gynecological malignancies. However, preoperative identification of pathological LNs remains a significant challenge with current imaging modalities. Full-field optical coherence tomography (FF-OCT) is a non-invasive microscopic technique based on tissue reflectivity and light interference, providing real-time, high-resolution images in < 10 min, with no tissue preparation or alteration required. Our aim was to evaluate the diagnostic accuracy of FF-OCT in identifying LN metastatic foci measuring ≥ 0.2 mm in gynecological cancers, in an intraoperative setting. Comparative analysis of 80 fresh ex vivo LNs with FF-OCT versus gold standard pathology showed high accuracy (97.6%), sensitivity (92.3%), and specificity (98.2%) of FF-OCT. These results support the suitability of FF-OCT integration into clinical practice for real-time assessment of LN status, thereby improving intraoperative decision making while enabling subsequent routine histological analysis.