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<p>The purpose was to evaluate aqueous carbonic anhydrase-1(CA-1) expression and explore its correlation with macular structural changes and other cytokines in patients with macular edema (ME) secondary to retinal vein occlusion (RVO). This was a retrospective cross-sectional study in which patients with RVO (<i>n</i> = 109) and control subjects (<i>n</i> = 37) were included. The concentrations of cytokines, including CA-1, PPK/PK, ICAM, bFGF, VEGF and MCP-1, in the aqueous humor were measured before intravitreal injection of anti-VEGF drugs or DEX drugs. We collected optical coherence tomography (OCT) images before obtaining aqueous humor. CA-1 levels in the aqueous humor were greater in the RVO group than in the control group, and CA-1 levels were lower in treated RVO patients than in treatment-naïve patients. In addition, the levels of other cytokines (PPK/PK, ICAM, bFGF, VEGF and MCP-1) tended to be similar to those of CA-1. CA-1 was positively correlated with visual acuity (VA) logMAR (<i>r</i> = 0.215; <i>p</i> = 0.03), PPK/PK (<i>r</i> = 0.58, <i>p</i> &lt; 0.001), ICAM (<i>r</i> = 0.70, <i>p</i> &lt; 0.001), bFGF (<i>r</i> = 0.48, <i>p</i> &lt; 0.001), VEGF (<i>r</i> = 0.55, <i>p</i> &lt; 0.001), MCP (<i>r</i> = 0.67, <i>p</i> &lt; 0.001) and retinal hemorrhage (<i>r</i> = 0.309, <i>p</i> = 0.003) in RVO patients. In conclusion, CA-1 was overexpressed in RVO patients, especially in treatment-naïve patients. Additionally, increased CA-1 levels are associated with other aqueous cytokines, VA logMAR values and retinal hemorrhage in RVO patients.</p>

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Aqueous carbonic anhydrase-1 overexpression and its association with cytokine profiles and macular structural changes in retinal vein occlusion-associated macular edema

  • 期刊论文

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  • 发表日期：

    2025年8月21日

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  • Xiaoshuang Jiang,
  • Pengfei Ren,
  • Xiao Ke,
  • Yonghao Zhao,
  • Jingxin Zeng,
  • Guina Liu,
  • Jie Liu,
  • Wenwen Shang,
  • Fang Lu

摘要

The purpose was to evaluate aqueous carbonic anhydrase-1(CA-1) expression and explore its correlation with macular structural changes and other cytokines in patients with macular edema (ME) secondary to retinal vein occlusion (RVO). This was a retrospective cross-sectional study in which patients with RVO (n = 109) and control subjects (n = 37) were included. The concentrations of cytokines, including CA-1, PPK/PK, ICAM, bFGF, VEGF and MCP-1, in the aqueous humor were measured before intravitreal injection of anti-VEGF drugs or DEX drugs. We collected optical coherence tomography (OCT) images before obtaining aqueous humor. CA-1 levels in the aqueous humor were greater in the RVO group than in the control group, and CA-1 levels were lower in treated RVO patients than in treatment-naïve patients. In addition, the levels of other cytokines (PPK/PK, ICAM, bFGF, VEGF and MCP-1) tended to be similar to those of CA-1. CA-1 was positively correlated with visual acuity (VA) logMAR (r = 0.215; p = 0.03), PPK/PK (r = 0.58, p < 0.001), ICAM (r = 0.70, p < 0.001), bFGF (r = 0.48, p < 0.001), VEGF (r = 0.55, p < 0.001), MCP (r = 0.67, p < 0.001) and retinal hemorrhage (r = 0.309, p = 0.003) in RVO patients. In conclusion, CA-1 was overexpressed in RVO patients, especially in treatment-naïve patients. Additionally, increased CA-1 levels are associated with other aqueous cytokines, VA logMAR values and retinal hemorrhage in RVO patients.