Scholarlink

<p>This study explored associations between macular retinal nerve fiber layer (RNFL) thickness, brain volume, and cortical thickness in older adults. A total of 166 community-dwelling participants over 65 years old (mean 75.2 ± 5.3; 61.4% women) without dementia or ocular pathologies underwent 3D T1 MRI and macular RNFL thickness measurements using spectral-domain optical coherence tomography. Voxel-based morphometry, adjusting for age, sex, and total intracranial volume (uncorrected <i>p</i> &lt; 0.001, cluster size threshold ≥ 100 voxels), showed uncorrected correlations between outer RNFL thickness and gray matter volume in the right inferior parietal (t = 3.81), left superior frontal (t = 3.71), and left inferior temporal (t = 3.95) cortices, with total RNFL thickness linked to the right inferior parietal cortex (t = 3.62). Pearson’s correlation, adjusted for age and sex, showed RNFL thickness was weakly associated with cortical thickness in regions including the left posterior cingulate and supramarginal areas. All observed associations lost statistical significance after multiple comparisons. These preliminary findings suggest that macular RNFL thickness may be related to structural changes in brain regions involved in sensory processing and cognitive functions, but the statistical evidence was limited. Further longitudinal research is needed to assess its potential as a non-invasive biomarker for neurodegenerative processes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association of retinal layer thickness with brain volume and cortical thickness in older adults

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月29日

查看全文
  • Ji Won Han,
  • Hyeong Min Kim,
  • Min Jeong Kwon,
  • Jieun Park,
  • Jun Sung Kim,
  • Jae Hyoung Kim,
  • Se Joon Woo,
  • Ki Woong Kim

摘要

This study explored associations between macular retinal nerve fiber layer (RNFL) thickness, brain volume, and cortical thickness in older adults. A total of 166 community-dwelling participants over 65 years old (mean 75.2 ± 5.3; 61.4% women) without dementia or ocular pathologies underwent 3D T1 MRI and macular RNFL thickness measurements using spectral-domain optical coherence tomography. Voxel-based morphometry, adjusting for age, sex, and total intracranial volume (uncorrected p < 0.001, cluster size threshold ≥ 100 voxels), showed uncorrected correlations between outer RNFL thickness and gray matter volume in the right inferior parietal (t = 3.81), left superior frontal (t = 3.71), and left inferior temporal (t = 3.95) cortices, with total RNFL thickness linked to the right inferior parietal cortex (t = 3.62). Pearson’s correlation, adjusted for age and sex, showed RNFL thickness was weakly associated with cortical thickness in regions including the left posterior cingulate and supramarginal areas. All observed associations lost statistical significance after multiple comparisons. These preliminary findings suggest that macular RNFL thickness may be related to structural changes in brain regions involved in sensory processing and cognitive functions, but the statistical evidence was limited. Further longitudinal research is needed to assess its potential as a non-invasive biomarker for neurodegenerative processes.