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<p>Preliminary evidence suggests that ayahuasca may alleviate severe grief symptoms. This three-arm, sequentially allocated, open-label study examines the therapeutic changes associated with ayahuasca-assisted meaning reconstruction therapy (A-MR) compared to meaning reconstruction therapy alone (MR) and a no-treatment control (NT). A total of 84 adults experiencing severe grief within 12 months of losing a first-degree relative were allocated to A-MR (<i>n</i> = 28), MR (<i>n</i> = 28), or NT (<i>n</i> = 28). Grief severity, prolonged grief disorder symptoms, post-traumatic growth, and quality of life were assessed at baseline, after the intervention, and 3 months post-intervention. Ayahuasca was well tolerated, with no serious adverse events reported. All groups showed significant grief severity reduction (A-MR: <i>p</i> &lt; .0001, <i>d</i> = 2.44; MR: <i>p</i> &lt; .0001, <i>d</i> = 1.84; NT: <i>p</i> &lt; .002, <i>d</i> = 0.74). Greater reductions were observed in the A-MR compared to MR (<i>p</i> = .012, <i>d</i> = 0.86) and NT (<i>p</i> = .0008, <i>d</i> = 1.07). A-MR was also associated with significant improvements in prolonged grief symptomatology, post-traumatic growth, and quality of life, with medium-to-large effect sizes. This is the first controlled prospective study to provide preliminary support for A-MR as a safe and potentially effective intervention for severe grief, though replication in larger randomized trials is required.</p>

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Ayahuasca-assisted meaning reconstruction therapy as an early resource for bereavement: a non-randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月1日

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  • Oscar Soto-Angona,
  • Oscar Andión,
  • Pablo Sabucedo,
  • Robert A. Neimeyer,
  • Josep Maria Haro,
  • Julia Javkin,
  • Magí Farré,
  • Débora González

摘要

Preliminary evidence suggests that ayahuasca may alleviate severe grief symptoms. This three-arm, sequentially allocated, open-label study examines the therapeutic changes associated with ayahuasca-assisted meaning reconstruction therapy (A-MR) compared to meaning reconstruction therapy alone (MR) and a no-treatment control (NT). A total of 84 adults experiencing severe grief within 12 months of losing a first-degree relative were allocated to A-MR (n = 28), MR (n = 28), or NT (n = 28). Grief severity, prolonged grief disorder symptoms, post-traumatic growth, and quality of life were assessed at baseline, after the intervention, and 3 months post-intervention. Ayahuasca was well tolerated, with no serious adverse events reported. All groups showed significant grief severity reduction (A-MR: p < .0001, d = 2.44; MR: p < .0001, d = 1.84; NT: p < .002, d = 0.74). Greater reductions were observed in the A-MR compared to MR (p = .012, d = 0.86) and NT (p = .0008, d = 1.07). A-MR was also associated with significant improvements in prolonged grief symptomatology, post-traumatic growth, and quality of life, with medium-to-large effect sizes. This is the first controlled prospective study to provide preliminary support for A-MR as a safe and potentially effective intervention for severe grief, though replication in larger randomized trials is required.