<p>The examination of the current-voltage properties of protein chains connected to armchair graphene nanoribbon leads is performed using the tight-binding Hamiltonian approach in conjunction with the Landauer–Büttiker formalism. The nonlinear current-voltage behavior for three different conformations of the protein structures is calculated and evaluated in connection with the corresponding transmission probabilities. The characteristics of current-voltage demonstrate fluctuations in relation to variations in temperature or the width of the electrodes, with modifications in the conformations of protein chains also playing a significant role in these phenomena. An increase in coupling is associated with a corresponding rise in electric current, suggesting a strong interaction between the electrodes and the device. This research serves as a benchmark for potential investigations into diseases or for future applications within the realm of nanotechnology.</p>