Scholarlink

<p>Lung adenocarcinoma is a globally prevalent malignant tumor with a high death rate, notorious for its invasive and metastatic capabilities. SGO2 is a key protein in the cell division process, influencing the development of various malignant tumors. However, research on the biological functions of SGO2 in Lung adenocarcinoma remains limited. By utilizing the Cancer Genome Atlas (TCGA) database, we performed an analysis of SGO2 expression levels in a cohort comprising 206 Lung adenocarcinoma patients in comparison to 200 non-neoplastic control specimens. Subsequently, we validated our findings through immunohistochemical staining in a subset of 21 Lung adenocarcinoma cases from Nanjing Second Hospital. Furthermore, the functional role of SGO2 in the H1299 cell line was assessed through a series of experiments including Western blotting, CCK-8 assays, Transwell assays for invasion, wound healing assays, and flow cytometric analysis. The study also explored the influence of SGO2 on the regulation of MAD2 expression. The enhancement of SGO2 expression in Lung adenocarcinoma tissues was significantly associated with a poor prognosis in patients. A reduction in SGO2 expression markedly decreased the proliferative, migratory, and invasive capabilities of H1299 cells, a phenomenon that may be attributed to the regulation of MAD2 expression by SGO2. SGO2 exerted a pivotal influence on the metastatic behavior of Lung adenocarcinoma cells by governing the expression of MAD2, thereby contributing substantially to the molecular pathogenesis of Lung adenocarcinoma.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Elevated SGO2 expression in lung adenocarcinoma promotes migration and invasion via MAD2 and correlates with poor prognosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月15日

查看全文
  • Min Sun,
  • Wenzheng Zhou,
  • Guohao Wei,
  • Mengyao Lv,
  • Yan Sun,
  • Huihui Zhao,
  • Chuandong Zhu

摘要

Lung adenocarcinoma is a globally prevalent malignant tumor with a high death rate, notorious for its invasive and metastatic capabilities. SGO2 is a key protein in the cell division process, influencing the development of various malignant tumors. However, research on the biological functions of SGO2 in Lung adenocarcinoma remains limited. By utilizing the Cancer Genome Atlas (TCGA) database, we performed an analysis of SGO2 expression levels in a cohort comprising 206 Lung adenocarcinoma patients in comparison to 200 non-neoplastic control specimens. Subsequently, we validated our findings through immunohistochemical staining in a subset of 21 Lung adenocarcinoma cases from Nanjing Second Hospital. Furthermore, the functional role of SGO2 in the H1299 cell line was assessed through a series of experiments including Western blotting, CCK-8 assays, Transwell assays for invasion, wound healing assays, and flow cytometric analysis. The study also explored the influence of SGO2 on the regulation of MAD2 expression. The enhancement of SGO2 expression in Lung adenocarcinoma tissues was significantly associated with a poor prognosis in patients. A reduction in SGO2 expression markedly decreased the proliferative, migratory, and invasive capabilities of H1299 cells, a phenomenon that may be attributed to the regulation of MAD2 expression by SGO2. SGO2 exerted a pivotal influence on the metastatic behavior of Lung adenocarcinoma cells by governing the expression of MAD2, thereby contributing substantially to the molecular pathogenesis of Lung adenocarcinoma.