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<p>Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays a vital role in regulating behavior, mood, memory, and gastrointestinal homeostasis. Although recent studies have identified an intestine-hair follicle link, potentially implicating 5-HT, its exact relationship with hair growth remains unclear. Here we investigated the effects of serotonin signaling on hair follicle homeostasis. Gene expression analysis showed significant upregulation of hair growth-related genes in dermal papilla cells treated with 5-HT.&#xa0;The hair growth-promoting effects of 5-HT were examined using hair follicle organoids and hair follicle organ cultures. The addition of 5-HT to hair follicle organoids and hair follicles promoted hair shaft elongation. Similar effects were observed with sumatriptan succinate, a 5-HT receptor agonist. These results suggest that targeting serotonin signaling can advance alopecia therapy.</p>

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Serotonin activates dermal papilla cells and promotes hair growth

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月8日

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  • Tatsuto Kageyama,
  • Jieun Seo,
  • Lei Yan,
  • Sayuri Hamano,
  • Junji Fukuda

摘要

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays a vital role in regulating behavior, mood, memory, and gastrointestinal homeostasis. Although recent studies have identified an intestine-hair follicle link, potentially implicating 5-HT, its exact relationship with hair growth remains unclear. Here we investigated the effects of serotonin signaling on hair follicle homeostasis. Gene expression analysis showed significant upregulation of hair growth-related genes in dermal papilla cells treated with 5-HT. The hair growth-promoting effects of 5-HT were examined using hair follicle organoids and hair follicle organ cultures. The addition of 5-HT to hair follicle organoids and hair follicles promoted hair shaft elongation. Similar effects were observed with sumatriptan succinate, a 5-HT receptor agonist. These results suggest that targeting serotonin signaling can advance alopecia therapy.