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<p><i>Pseudomonas aeruginosa</i> may colonize humans, however, epidemiological data are scarce. Here, we determined overall and body site-specific carriage rates and associated risk factors among healthy individuals and newly admitted patients in three major cities. This cross-sectional study was conducted in Rotterdam (The Netherlands), Rome (Italy), and Jakarta (Indonesia) between 2022–2024. Adult healthy individuals and newly admitted patients were asked to provide throat, navel, and rectal/perianal swabs, and to complete a questionnaire. Univariable and multivariable analyses were performed to determine factors associated with <i>P. aeruginosa</i> carriage. Carriage rates differed significantly between cities (p &lt; 0.001), and were lowest in Rome (healthy individuals 4.8%; patients 6.5%), followed by Rotterdam (healthy individuals 12.0%; patients 12.7%), and Jakarta (healthy individuals 28.6%; patients 24.0%). In carriers from Rotterdam, <i>P. aeruginosa</i> was most often detected in perianal swabs, while mostly in throat swabs among carriers from Rome and Jakarta. <i>P. aeruginosa</i> carriage had a seasonal association in patients from Rotterdam (p = 0.014) and Jakarta (p = 0.020). Among patients from Jakarta, female sex (aOR 1.98, 95% CI 1.02–3.84; p = 0.045) was associated with <i>P. aeruginosa</i> carriage. Overall, <i>P. aeruginosa</i> carriage rates and colonized body sites differ between cities and are likely associated with climate differences. Our findings warrant setting-specific adaptations of screening strategies and surveillance programs.</p>

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Pseudomonas aeruginosa carriage and associated risk factors in healthy individuals and patients from Rotterdam, Rome, and Jakarta

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月21日

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  • Anneloes van Veen,
  • Selvi N. Shahab,
  • Amber Rijfkogel,
  • Margreet C. Vos,
  • Yulia Rosa Saharman,
  • Anis Karuniawati,
  • Silvia Zelli,
  • Desy De Lorenzis,
  • Giulia Menchinelli,
  • Giulia De Angelis,
  • Maurizio Sanguinetti,
  • Anne F. Voor in ’t holt,
  • Juliëtte A. Severin,
  • Corné H. W. Klaassen,
  • Anniek E. E. de Jong,
  • Merel Kemper,
  • Heike Schmitt,
  • Sima Mohammadi,
  • Valentine Renaud,
  • Irena Kukavica-Ibrulj,
  • Marianne Potvin,
  • Guillaume Q. Nguyen,
  • Jeff Gauthier,
  • Roger Levesque

摘要

Pseudomonas aeruginosa may colonize humans, however, epidemiological data are scarce. Here, we determined overall and body site-specific carriage rates and associated risk factors among healthy individuals and newly admitted patients in three major cities. This cross-sectional study was conducted in Rotterdam (The Netherlands), Rome (Italy), and Jakarta (Indonesia) between 2022–2024. Adult healthy individuals and newly admitted patients were asked to provide throat, navel, and rectal/perianal swabs, and to complete a questionnaire. Univariable and multivariable analyses were performed to determine factors associated with P. aeruginosa carriage. Carriage rates differed significantly between cities (p < 0.001), and were lowest in Rome (healthy individuals 4.8%; patients 6.5%), followed by Rotterdam (healthy individuals 12.0%; patients 12.7%), and Jakarta (healthy individuals 28.6%; patients 24.0%). In carriers from Rotterdam, P. aeruginosa was most often detected in perianal swabs, while mostly in throat swabs among carriers from Rome and Jakarta. P. aeruginosa carriage had a seasonal association in patients from Rotterdam (p = 0.014) and Jakarta (p = 0.020). Among patients from Jakarta, female sex (aOR 1.98, 95% CI 1.02–3.84; p = 0.045) was associated with P. aeruginosa carriage. Overall, P. aeruginosa carriage rates and colonized body sites differ between cities and are likely associated with climate differences. Our findings warrant setting-specific adaptations of screening strategies and surveillance programs.