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<p>The olm (<i>Proteus anguinus</i>), with a predicted maximum lifespan of more than 100&#xa0;years, is the longest-lived amphibian, which in addition possesses a range of unique adaptations to its dark, subterranean cave habitat. To assess the underlying molecular signatures, we present the first comprehensive transcriptome of the olm. Our study provides gene expression data across six organs and comparative genomics analyses, accessible via an interactive web server: <a href="http://comp-pheno.de/olm">http://comp-pheno.de/olm</a>. The data uncover significant organ-specific gene expression, with the brain showing the highest number of organ-specific expressed genes. Our findings reveal significantly more genes under strong negative selection than positive selection, particularly in brain-specific expressed genes. Processes under positive selection in the olm resemble those in other long-lived species.</p>

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The transcriptome of the olm provides insights into its evolution and gene expression

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月3日

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  • Susanne Holtze,
  • Defne Demirtürk,
  • Oliver Ohlenschläger,
  • Simon Hegele,
  • Kanstantsin Siniuk,
  • Silke Förste,
  • Venket Raghavan,
  • Marco Groth,
  • Martin Bens,
  • Nils Hassel,
  • An Martel,
  • Maja Lukač,
  • Ivan Cizelj,
  • Martin Fischer,
  • Hequn Liu,
  • Thomas B. Hildebrandt,
  • Steve Hoffmann,
  • Arne Sahm

摘要

The olm (Proteus anguinus), with a predicted maximum lifespan of more than 100 years, is the longest-lived amphibian, which in addition possesses a range of unique adaptations to its dark, subterranean cave habitat. To assess the underlying molecular signatures, we present the first comprehensive transcriptome of the olm. Our study provides gene expression data across six organs and comparative genomics analyses, accessible via an interactive web server: http://comp-pheno.de/olm. The data uncover significant organ-specific gene expression, with the brain showing the highest number of organ-specific expressed genes. Our findings reveal significantly more genes under strong negative selection than positive selection, particularly in brain-specific expressed genes. Processes under positive selection in the olm resemble those in other long-lived species.