<p>A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, <sup>1</sup>H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of chromeno[4,3-<i>d</i>]pyrimidines from the reaction of 4-hydroxy-coumarin, urea/thiourea and aldehyde under solvent-free conditions at 80&#xa0;°C in high yields and short reaction times.</p>

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Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines

  • Afagh Ranjbaran,
  • Davood Habibi,
  • Arezo Monem,
  • Nastaran Dehnokhalaji

摘要

A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, 1H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of chromeno[4,3-d]pyrimidines from the reaction of 4-hydroxy-coumarin, urea/thiourea and aldehyde under solvent-free conditions at 80 °C in high yields and short reaction times.