Scholarlink

<p>The albumin-to-globulin ratio (AGR) has been associated with infectious diseases; however, its association with pneumonia in patients with aneurysmal subarachnoid hemorrhage (aSAH) is unclear. This research aims to investigate the connection between AGR and hospital-acquired pneumonia (HAP). This retrospective analysis included 4,813 patients with aSAH from West China Hospital, Sichuan University. Serum samples were collected within seven days after admission. Logistic regression analysis was conducted to assess the association between AGR and HAP. Among the 4,813 patients, 1,249 (26.0%) developed HAP. The patients were classified into quartiles according to their AGR levels. Significant differences in odds ratios (ORs) were found in admission AGR: 0.76 (95% CI 0.63–0.93, <i>p</i> = 0.007) for Q2, 0.78 (95% CI 0.64–0.94, <i>p</i> = 0.016) for Q3, and 0.77 (95% CI 0.63–0.94, <i>p</i> = 0.012) for Q4 versus Q1. ORs of minimum AGR were: 0.67 (95% CI 0.57–0.80, <i>p</i> &lt; 0.001) for Q2, 0.45(95% CI 0.37–0.54, <i>p</i> &lt; 0.001) for Q3, and 0.24 (95% CI 0.20–0.30, <i>p</i> &lt; 0.001) for Q4. ORs for AGR drift: 1.19 (95% CI 0.93–1.52, <i>p</i> = 0.18) for Q2, 1.35 (95% CI 1.06–1.73, <i>p</i> = 0.015) for Q3, and 2.00 (95% CI 1.57–2.55, <i>p</i> &lt; 0.001) for Q4. Furthermore, admission AGR (&lt; 1.21) and minimum AGR (&lt; 0.99) were linked to elevated CURB-65 scores<sup><CitationRef AdditionalCitationIDS="CR4" CitationID="CR3">3</CitationRef>–<CitationRef CitationID="CR5">5</CitationRef></sup> in HAP patients, yielding ORs of 0.46 (95% CI 0.27–0.77, <i>p</i> = 0.003) and 0.44 (95% CI 0.27–0.69, <i>p</i> &lt; 0.001). AGR was associated with an increased risk of HAP. Furthermore, lower minimum AGR was associated with increased severity of HAP among aSAH patients. Further research is necessary to confirm this finding and investigate the underlying mechanisms.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between albumin to Globulin ratio and pneumonia in patients with aneurysmal subarachnoid hemorrhage

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月16日

查看全文
  • Yangchun Xiao,
  • Yu Zhang,
  • Xin Cheng,
  • Lvlin Cheng,
  • Yixin Tian,
  • Jialing He,
  • Wenqing Wang,
  • Wenhua Tang,
  • Chao You,
  • Fang Fang

摘要

The albumin-to-globulin ratio (AGR) has been associated with infectious diseases; however, its association with pneumonia in patients with aneurysmal subarachnoid hemorrhage (aSAH) is unclear. This research aims to investigate the connection between AGR and hospital-acquired pneumonia (HAP). This retrospective analysis included 4,813 patients with aSAH from West China Hospital, Sichuan University. Serum samples were collected within seven days after admission. Logistic regression analysis was conducted to assess the association between AGR and HAP. Among the 4,813 patients, 1,249 (26.0%) developed HAP. The patients were classified into quartiles according to their AGR levels. Significant differences in odds ratios (ORs) were found in admission AGR: 0.76 (95% CI 0.63–0.93, p = 0.007) for Q2, 0.78 (95% CI 0.64–0.94, p = 0.016) for Q3, and 0.77 (95% CI 0.63–0.94, p = 0.012) for Q4 versus Q1. ORs of minimum AGR were: 0.67 (95% CI 0.57–0.80, p < 0.001) for Q2, 0.45(95% CI 0.37–0.54, p < 0.001) for Q3, and 0.24 (95% CI 0.20–0.30, p < 0.001) for Q4. ORs for AGR drift: 1.19 (95% CI 0.93–1.52, p = 0.18) for Q2, 1.35 (95% CI 1.06–1.73, p = 0.015) for Q3, and 2.00 (95% CI 1.57–2.55, p < 0.001) for Q4. Furthermore, admission AGR (< 1.21) and minimum AGR (< 0.99) were linked to elevated CURB-65 scores3–5 in HAP patients, yielding ORs of 0.46 (95% CI 0.27–0.77, p = 0.003) and 0.44 (95% CI 0.27–0.69, p < 0.001). AGR was associated with an increased risk of HAP. Furthermore, lower minimum AGR was associated with increased severity of HAP among aSAH patients. Further research is necessary to confirm this finding and investigate the underlying mechanisms.