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<p>The green synthesis of multifunctional Ag/ZnO nanodots using <i>Artemisia austroyunnanensis</i> leaf extract was explored for their antibacterial, antioxidant, and anticancer properties. Characterization techniques confirmed the successful synthesis of nanodots with a nanoscale size (9.02 ± 1.58&#xa0;nm), high crystallinity, and distinct ZnO and Ag phases. The synthesized nanodots exhibited significant antibacterial activity against Gram-positive and Gram-negative bacteria, with the largest zone of inhibition observed for <i>Salmonella typhimurium</i> (21 ± 1&#xa0;mm at 300&#xa0;µg/mL). Antioxidant assays demonstrated robust free radical scavenging activity, particularly in the ABTS assay (IC<sub>50</sub> = 31.85 ± 0.75&#xa0;µg/mL), attributed to the synergistic effects of ZnO, Ag, and bioactive plant compounds. Cytotoxicity against SHSY5Y neuroblastoma cells revealed dose-dependent activity, with an IC<sub>50</sub> value of 193.23&#xa0;µg/mL, underscoring their potential as anticancer agents. Molecular docking studies highlighted strong binding affinities of <i>Artemisia</i> phytochemicals, particularly artemisinin (− 9.1&#xa0;kcal/mol), with the p53 tumor suppressor protein, validating their therapeutic potential. These findings demonstrate the efficacy of biogenic Ag/ZnO nanodots as eco-friendly, multifunctional therapeutic agents for bacterial infections and neuroblastoma treatment, offering an innovative approach in sustainable nanomedicine.</p>

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Ag/ZnO nanodots from Artemisia austroyunnanensis as antibacterial and anticancer agents against human neuroblastoma cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月2日

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  • Kushankur Sarkar,
  • Sangita Dey,
  • Zakia Farhat,
  • Anoop Kumar,
  • Chandrani Choudhuri,
  • Monoranjan Chowdhury

摘要

The green synthesis of multifunctional Ag/ZnO nanodots using Artemisia austroyunnanensis leaf extract was explored for their antibacterial, antioxidant, and anticancer properties. Characterization techniques confirmed the successful synthesis of nanodots with a nanoscale size (9.02 ± 1.58 nm), high crystallinity, and distinct ZnO and Ag phases. The synthesized nanodots exhibited significant antibacterial activity against Gram-positive and Gram-negative bacteria, with the largest zone of inhibition observed for Salmonella typhimurium (21 ± 1 mm at 300 µg/mL). Antioxidant assays demonstrated robust free radical scavenging activity, particularly in the ABTS assay (IC50 = 31.85 ± 0.75 µg/mL), attributed to the synergistic effects of ZnO, Ag, and bioactive plant compounds. Cytotoxicity against SHSY5Y neuroblastoma cells revealed dose-dependent activity, with an IC50 value of 193.23 µg/mL, underscoring their potential as anticancer agents. Molecular docking studies highlighted strong binding affinities of Artemisia phytochemicals, particularly artemisinin (− 9.1 kcal/mol), with the p53 tumor suppressor protein, validating their therapeutic potential. These findings demonstrate the efficacy of biogenic Ag/ZnO nanodots as eco-friendly, multifunctional therapeutic agents for bacterial infections and neuroblastoma treatment, offering an innovative approach in sustainable nanomedicine.