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<p>Natural plant active compounds can be applied to treat infected wounds due to their antibacterial and antioxidant properties. However, because of their degradable nature, these compounds must be coated in polymeric structures, such as chitosan (CS). Single-wall carbon nanotubes (SWCNTs) are incorporated into CS to enhance its mechanical properties. This study investigated the effects of hydrogels prepared from CS/SWCNTs and linalool (CS/SWCNTs/Lin) on the treatment of infected wounds in a mouse model. The physicochemical properties of the prepared structures were examined, along with in vitro release, cytotoxicity, and antibacterial properties. Wound contraction, total bacterial count, histopathological parameters, and the expressions of BCL-2 (B-cell lymphoma-2), Beclin-1, Caspase-3, c-Myc, Glutathione peroxidase (GPx), P53, superoxide dismutase (SOD), transforming growth factor beta (TGF-β), and collagen type I (COL-1A), as well as serum concentrations of total antioxidant capacity (TAC) and malondialdehyde (MDA), were investigated. The physicochemical properties confirmed the successful synthesis of the structures, and CS/SWCNTs reduced the rapid release of linalool within the first 24&#xa0;h. The results also confirmed the safety and antibacterial properties of the structures. The administration of hydrogels significantly reduced the total bacterial count and edema, accelerated the wound healing process, and increased the expression of Beclin-1, BCL-2, Caspase-3, c-Myc, GPx, SOD, P53, TGF-β, and collagen 1A, as well as the serum concentration of TAC compared to control groups. In summary, CS/SWCNTs/Lin hydrogels accelerated the wound healing process by influencing the expression of apoptotic molecules and antioxidant factors in an infected wound model in mice.</p>

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The synergistic effects of linalool and chitosan-carbon nanotubes enhance the healing of infectious wounds

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月30日

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  • Mohaddase Ehsanifard,
  • Mohammad Reza Farahpour,
  • Zohreh Ghazi Tabatabaei

摘要

Natural plant active compounds can be applied to treat infected wounds due to their antibacterial and antioxidant properties. However, because of their degradable nature, these compounds must be coated in polymeric structures, such as chitosan (CS). Single-wall carbon nanotubes (SWCNTs) are incorporated into CS to enhance its mechanical properties. This study investigated the effects of hydrogels prepared from CS/SWCNTs and linalool (CS/SWCNTs/Lin) on the treatment of infected wounds in a mouse model. The physicochemical properties of the prepared structures were examined, along with in vitro release, cytotoxicity, and antibacterial properties. Wound contraction, total bacterial count, histopathological parameters, and the expressions of BCL-2 (B-cell lymphoma-2), Beclin-1, Caspase-3, c-Myc, Glutathione peroxidase (GPx), P53, superoxide dismutase (SOD), transforming growth factor beta (TGF-β), and collagen type I (COL-1A), as well as serum concentrations of total antioxidant capacity (TAC) and malondialdehyde (MDA), were investigated. The physicochemical properties confirmed the successful synthesis of the structures, and CS/SWCNTs reduced the rapid release of linalool within the first 24 h. The results also confirmed the safety and antibacterial properties of the structures. The administration of hydrogels significantly reduced the total bacterial count and edema, accelerated the wound healing process, and increased the expression of Beclin-1, BCL-2, Caspase-3, c-Myc, GPx, SOD, P53, TGF-β, and collagen 1A, as well as the serum concentration of TAC compared to control groups. In summary, CS/SWCNTs/Lin hydrogels accelerated the wound healing process by influencing the expression of apoptotic molecules and antioxidant factors in an infected wound model in mice.