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<p>Overweight and obesity are major global public health concerns, and they are increasingly recognized as side effects of long-term antiretroviral therapy (ART) in people living with HIV (PLHIV). As ART improves life expectancy, weight gain and associated comorbidities have emerged as new challenges in HIV care. This study aimed to determine the prevalence and associated factors with overweight and obesity among people living with HIV(PLHIV) on antiretroviral therapy (ART) in Benin’s National Teaching Hospital. A prospective cross-sectional study was conducted over a three-month period, from December 17, 2023, to February 10, 2024. Data were collected through structured interviews and medical record reviews. Statistical analyses included descriptive statistics, univariable, and multivariable logistic regression to assess associations between overweight/obesity and demographic, clinical, and lifestyle factors. The prevalence of overweight and obesity in the study population was 49.4%, with a significantly higher prevalence in females (36.8%) than males (12.6%). Multivariable analysis identified female sex (aOR: 2.4; 95% CI: 1.5–4.1; <i>p</i> &lt; 0.001) and hypertension (aOR: 2.5; 95% CI: 1.6–4.1; <i>p</i> &lt; 0.001) as strong independent predictors of overweight and obesity. Conversely, a high viral load (&gt; 1000 copies/ml) was inversely associated with excess weight (aOR: 0.4; 95% CI: 0.2–0.9; <i>p</i> = 0.050). In summary, nearly half of PLHIV on ART were overweight or obese. Female sex and hypertension increased the risk, while high viral load was linked to lower weight. These findings underline the need for integrated care approaches that address weight management in HIV treatment programs.</p>

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Prevalence and associated factors of overweight and obesity among people living with HIV on antiretroviral therapy in a national hospital in Benin

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月10日

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  • Olushina Ayo Junior Ale,
  • Boni Maxime Ale,
  • Oswald Lionel Koutangni,
  • Simon Giscard Akpi,
  • Adébiyi Raphaël K. Alogou,
  • Kenneth Geovania Dèlonou Damassoh,
  • Eric Youm,
  • Nelly Njeri Wakaba,
  • Calixte Oswald Assogba,
  • Harold Tankpinou Zoumenou,
  • Franck Amahowe,
  • Franck Biaou Guy Ale

摘要

Overweight and obesity are major global public health concerns, and they are increasingly recognized as side effects of long-term antiretroviral therapy (ART) in people living with HIV (PLHIV). As ART improves life expectancy, weight gain and associated comorbidities have emerged as new challenges in HIV care. This study aimed to determine the prevalence and associated factors with overweight and obesity among people living with HIV(PLHIV) on antiretroviral therapy (ART) in Benin’s National Teaching Hospital. A prospective cross-sectional study was conducted over a three-month period, from December 17, 2023, to February 10, 2024. Data were collected through structured interviews and medical record reviews. Statistical analyses included descriptive statistics, univariable, and multivariable logistic regression to assess associations between overweight/obesity and demographic, clinical, and lifestyle factors. The prevalence of overweight and obesity in the study population was 49.4%, with a significantly higher prevalence in females (36.8%) than males (12.6%). Multivariable analysis identified female sex (aOR: 2.4; 95% CI: 1.5–4.1; p < 0.001) and hypertension (aOR: 2.5; 95% CI: 1.6–4.1; p < 0.001) as strong independent predictors of overweight and obesity. Conversely, a high viral load (> 1000 copies/ml) was inversely associated with excess weight (aOR: 0.4; 95% CI: 0.2–0.9; p = 0.050). In summary, nearly half of PLHIV on ART were overweight or obese. Female sex and hypertension increased the risk, while high viral load was linked to lower weight. These findings underline the need for integrated care approaches that address weight management in HIV treatment programs.