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<p>We tested whether leg fat mass is associated with insulin sensitivity, metabolic syndrome components, inflammatory markers, and impaired pancreatic β-cell function in a setting where body composition is less related to socioeconomic status. Leg fat (relative to body fat) by DXA, surrogate measures of insulin sensitivity and pancreatic β cell function inferred from serum insulin kinetics during a 75&#xa0;g oral glucose tolerance test (OGTT), metabolic syndrome components, and inflammatory markers, were measured in middle-aged Japanese parents of university students, whose BMI averaged &lt; 23.0&#xa0;kg/m<sup>2</sup> and homeostasis model assessment insulin resistance (HOMA-IR) &lt; 1.5. Low leg fat was associated with high HOMA-IR, adipose insulin resistance index (a product of fasting insulin and free fatty acid), OGTT-derived hepatic insulin resistance, and low Matsuda index. In addition, low leg fat was associated with a low disposition index (insulin resistance-adjusted insulin secretion) and high fasting and post-glucose glycemia. Further, it was related to high triglycerides, blood pressure, liver enzymes, and low HDL cholesterol. Finally, low leg fat was associated with high C-reactive protein and orosomucoid, acute phase proteins, and high leucocyte counts. The present study suggests that the percentage leg fat mass should be considered in assessing cardiometabolic risk stratification.</p>

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Low leg fat mass is associated with low insulin sensitivity, inflammatory markers, and β-cell dysfunction in non-obese Japanese people

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Satomi Minato-Inokawa,
  • Mari Honda,
  • Ayaka Tsuboi-Kaji,
  • Mika Takeuchi,
  • Kaori Kitaoka,
  • Miki Kurata,
  • Bin Wu,
  • Tsutomu Kazumi,
  • Keisuke Fukuo

摘要

We tested whether leg fat mass is associated with insulin sensitivity, metabolic syndrome components, inflammatory markers, and impaired pancreatic β-cell function in a setting where body composition is less related to socioeconomic status. Leg fat (relative to body fat) by DXA, surrogate measures of insulin sensitivity and pancreatic β cell function inferred from serum insulin kinetics during a 75 g oral glucose tolerance test (OGTT), metabolic syndrome components, and inflammatory markers, were measured in middle-aged Japanese parents of university students, whose BMI averaged < 23.0 kg/m2 and homeostasis model assessment insulin resistance (HOMA-IR) < 1.5. Low leg fat was associated with high HOMA-IR, adipose insulin resistance index (a product of fasting insulin and free fatty acid), OGTT-derived hepatic insulin resistance, and low Matsuda index. In addition, low leg fat was associated with a low disposition index (insulin resistance-adjusted insulin secretion) and high fasting and post-glucose glycemia. Further, it was related to high triglycerides, blood pressure, liver enzymes, and low HDL cholesterol. Finally, low leg fat was associated with high C-reactive protein and orosomucoid, acute phase proteins, and high leucocyte counts. The present study suggests that the percentage leg fat mass should be considered in assessing cardiometabolic risk stratification.