Scholarlink

<p>Despite the breakthrough achievements in understanding structural and functional alterations of brain connectivity in autism spectrum disorder (ASD), the exact nature and type of such alterations are not yet clear due to conflicting reports of hyper-connectivity, hypo-connectivity, and—in some cases—combinations of both. In this work, we bring order to the debate using a network comparison technique to capture mesoscopic-scale differential patterns of functional connectedness. In particular, we leverage recent algorithmic advances in extracting contrast subgraphs to identify maximally different mesoscopic connectivity structures between two sets of networks from typically developed individuals and ASD subjects across different developmental stages. A significantly larger connectivity among occipital cortex regions and between the left precuneus and the superior parietal gyrus was found in ASD subjects. At the same time, reduced connectivity characterized the superior frontal gyrus and the temporal lobe regions. More importantly, our results reconcile within a single framework multiple previous separate observations about functional connectivity alterations in ASD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Contrast subgraphs catch patterns of altered functional connectivity in autism spectrum disorder

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月7日

查看全文
  • Tommaso Lanciano,
  • Giovanni Petri,
  • Tommaso Gili,
  • Francesco Bonchi

摘要

Despite the breakthrough achievements in understanding structural and functional alterations of brain connectivity in autism spectrum disorder (ASD), the exact nature and type of such alterations are not yet clear due to conflicting reports of hyper-connectivity, hypo-connectivity, and—in some cases—combinations of both. In this work, we bring order to the debate using a network comparison technique to capture mesoscopic-scale differential patterns of functional connectedness. In particular, we leverage recent algorithmic advances in extracting contrast subgraphs to identify maximally different mesoscopic connectivity structures between two sets of networks from typically developed individuals and ASD subjects across different developmental stages. A significantly larger connectivity among occipital cortex regions and between the left precuneus and the superior parietal gyrus was found in ASD subjects. At the same time, reduced connectivity characterized the superior frontal gyrus and the temporal lobe regions. More importantly, our results reconcile within a single framework multiple previous separate observations about functional connectivity alterations in ASD.