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<p>Frailty is common in older adults; however, the central nervous system mechanisms underlying the differences between obesity and underweight remain unclear. This study investigated brain volume in frail, cognitively normal, community-dwelling older adults across three body mass index (BMI) groups: low (&lt; 18.5), intermediate (18.5–24.9), and high (≥  25.0). Whole and regional brain volumes were measured and analyzed. Among 3,627 participants, those in the high BMI group (<i>n</i> = 1,134) had significantly lower multivariate-adjusted total brain volume (66.8% vs. 67.3%, <i>p</i> &lt; 0.001) and gray matter volume (36.1% vs. 36.6%, <i>p</i> &lt; 0.001) than participants in the intermediate BMI group (<i>n</i> = 2,274). Volume differences were observed in the frontal, parietal, temporal, and cingulate cortices, as well as the hippocampal gyrus; amygdala; superior, middle, and inferior temporal gyri; temporal pole; parahippocampal gyrus; and cuneus. Compared with the intermediate BMI group, the low BMI group (<i>n</i> = 219) presented a significantly lower volume in the middle temporal gyrus (1.91% vs. 1.95%, <i>p</i> = 0.008). These findings indicate that older adults with frailty experience differences in brain volume, with atrophy patterns differing based on BMI. Therefore, the central nervous system dysfunction may play a role in the mechanisms underlying frailty.</p>

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Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月4日

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  • Naoki Ishizuka,
  • Hiroshi Akasaka,
  • Mitsunobu Sato,
  • Yuriko Sato,
  • Kazuki Hosokawa,
  • Junko Takahashi,
  • Hisashi Yonezawa,
  • Yasuo Terayama,
  • Tomoyuki Ohara,
  • Takanori Honda,
  • Mao Shibata,
  • Jun Hata,
  • Yasuko Tatewaki,
  • Yasuyuki Taki,
  • Tatsuya Mikami,
  • Kenjiro Ono,
  • Masaru Mimura,
  • Kenji Nakashima,
  • Jun-ichi Iga,
  • Minoru Takebayashi,
  • Toshiharu Ninomiya,
  • Tetsuya Maeda,
  • Toshiharu Ninomiya,
  • Mao Shibata,
  • Takanori Honda,
  • Jun Hata,
  • Tomoyuki Ohara,
  • Masato Akiyama,
  • Tetsuya Maeda,
  • Naoki Ishizuka,
  • Hiroshi Akasaka,
  • Junko Takahashi,
  • Hisashi Yonezawa,
  • Yasuo Terayama,
  • Yasuyuki Taki,
  • Yasuko Tatewaki,
  • Benjamin Thyreau,
  • Tatsuya Mikami,
  • Shigeyuki Nakaji,
  • Koichi Murashita,
  • Kaori Sawada,
  • Shintaro Yokoyama,
  • Kenjiro Ono,
  • Moeko Noguchi-Shinohara,
  • Kazuo Iwasa,
  • Sohshi Yuki-Nozaki,
  • Masahito Yamada,
  • Masaru Mimura,
  • Shogyoku Bun,
  • Hidehito Niimura,
  • Ryo Shikimoto,
  • Hisashi Kida,
  • Kenji Nakashima,
  • Yasuyo Fukada,
  • Hisanori Kowa,
  • Toshiya Nakano,
  • Kenji Wada,
  • Masafumi Kishi,
  • Jun-ichi Iga,
  • Tomoki Ozaki,
  • Ayumi Tachibana,
  • Yuta Yoshino,
  • Shu-ichi Ueno,
  • Minoru Takebayashi,
  • Naoto Kajitani,
  • Yusuke Miyagawa,
  • Tomohisa Ishikawa,
  • Seiji Yuki,
  • Ryuji Fukuhara,
  • Asuka Koyama,
  • Mamoru Hashimoto,
  • Manabu Ikeda,
  • Yoshihiro Kokubo,
  • Kazuhiro Uchida,
  • Midori Esaki,
  • Hisako Yoshida,
  • Kaori Muto,
  • Yusuke Inoue,
  • Izen Ri,
  • Yukihide Momozawa,
  • Chikashi Terao,
  • Michiaki Kubo,
  • Yutaka Kiyohara

摘要

Frailty is common in older adults; however, the central nervous system mechanisms underlying the differences between obesity and underweight remain unclear. This study investigated brain volume in frail, cognitively normal, community-dwelling older adults across three body mass index (BMI) groups: low (< 18.5), intermediate (18.5–24.9), and high (≥  25.0). Whole and regional brain volumes were measured and analyzed. Among 3,627 participants, those in the high BMI group (n = 1,134) had significantly lower multivariate-adjusted total brain volume (66.8% vs. 67.3%, p < 0.001) and gray matter volume (36.1% vs. 36.6%, p < 0.001) than participants in the intermediate BMI group (n = 2,274). Volume differences were observed in the frontal, parietal, temporal, and cingulate cortices, as well as the hippocampal gyrus; amygdala; superior, middle, and inferior temporal gyri; temporal pole; parahippocampal gyrus; and cuneus. Compared with the intermediate BMI group, the low BMI group (n = 219) presented a significantly lower volume in the middle temporal gyrus (1.91% vs. 1.95%, p = 0.008). These findings indicate that older adults with frailty experience differences in brain volume, with atrophy patterns differing based on BMI. Therefore, the central nervous system dysfunction may play a role in the mechanisms underlying frailty.