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<p>The relationship between maternal serum folate levels during pregnancy and febrile seizures (FS) in offspring remains unclear. This study assessed the association between maternal serum folate levels during late pregnancy and initial incidence of FS at 0–12, 13–24, and 25–36&#xa0;months of age, using data from the Japan Environment and Children’s Study, a nationwide birth cohort study. Among 100,303 live birth records, 92,129 were reviewed. The results revealed that maternal serum folate levels in the fourth quartile (Q4) were associated with a significantly lower incidence of FS at 0–12&#xa0;months of age compared with the reference quartile (Q1) (odds ratio [OR]: 0.71; 95% confidence interval [CI]: 0.59–0.87). However, at 25–36&#xa0;months of age, maternal serum folate levels in Q4 were associated with a significantly higher incidence of FS than in Q1 (OR: 1.18; 95% CI: 1.00–1.38). No correlation was observed at13–24&#xa0;months of age. These findings suggest that high maternal serum folate levels during late pregnancy might delay initial incidence of FS, reducing this initial incidence of FS at 0–12&#xa0;months of age and increasing it at 25–36&#xa0;months of age.</p>

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Association between maternal folate levels and febrile seizures in early childhood from the Japan Environment and Children’s Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Sachi Tokunaga,
  • Hideki Shimomura,
  • Masumi Okuda,
  • Yohei Taniguchi,
  • Naoko Taniguchi,
  • Tetsuro Fujino,
  • Masayuki Shima,
  • Yasuhiro Takeshima,
  • Michihiro Kamijima,
  • Shin Yamazaki,
  • Yukihiro Ohya,
  • Reiko Kishi,
  • Nobuo Yaegashi,
  • Koichi Hashimoto,
  • Chisato Mori,
  • Shuichi Ito,
  • Zentaro Yamagata,
  • Hidekuni Inadera,
  • Takeo Nakayama,
  • Tomotaka Sobue,
  • Masayuki Shima,
  • Seiji Kageyama,
  • Narufumi Suganuma,
  • Shoichi Ohga,
  • Takahiko Katoh

摘要

The relationship between maternal serum folate levels during pregnancy and febrile seizures (FS) in offspring remains unclear. This study assessed the association between maternal serum folate levels during late pregnancy and initial incidence of FS at 0–12, 13–24, and 25–36 months of age, using data from the Japan Environment and Children’s Study, a nationwide birth cohort study. Among 100,303 live birth records, 92,129 were reviewed. The results revealed that maternal serum folate levels in the fourth quartile (Q4) were associated with a significantly lower incidence of FS at 0–12 months of age compared with the reference quartile (Q1) (odds ratio [OR]: 0.71; 95% confidence interval [CI]: 0.59–0.87). However, at 25–36 months of age, maternal serum folate levels in Q4 were associated with a significantly higher incidence of FS than in Q1 (OR: 1.18; 95% CI: 1.00–1.38). No correlation was observed at13–24 months of age. These findings suggest that high maternal serum folate levels during late pregnancy might delay initial incidence of FS, reducing this initial incidence of FS at 0–12 months of age and increasing it at 25–36 months of age.