<p>This research explores the utilization of magnetohydrodynamic nanofluids to enhance thermal control in high-energy systems, such as X-ray devices, where efficient heat dissipation is essential for optimal performance and lifespan. By integrating analytical and numerical approaches, the study examines heat transfer in nanofluids confined between parallel plates, incorporating thermal radiation and the Cattaneo-Christov heat flux model. This model offers a more precise representation of heat transfer compared to traditional Fourier’s law, especially in scenarios involving rapid thermal fluctuations typical in X-ray equipment. The investigation employs similarity transformations to simplify the governing equations continuity, momentum, and energy transforming them into ordinary differential equations. These equations are then solved using the Homotopy Perturbation Method and the fourth-order Runge–Kutta technique. The study assesses the influence of various parameters, including magnetic field intensity, squeeze number, nanoparticle concentration, heat source, thermal relaxation, and radiation, on velocity and temperature profiles. The findings reveal that the Cattaneo-Christov model predicts lower temperature distributions compared to Fourier’s law, which is crucial for accurate thermal management in X-ray systems. Increasing the magnetic field strength results in reduced velocity and temperature due to the Lorentz force. Notably, the inclusion of nanoparticles significantly enhances heat transfer, making nanofluids a promising solution for cooling high-energy systems in radiology and X-ray machines.</p>