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<p>Herein, 4D-flow MRI was performed on the bilateral carotid arteries in a rat model of unilateral carotid artery injury to analyze changes in flow velocity, flow rate, wall shear stress (WSS), and cross-sectional area due to endothelial injury. MR images of the rat carotid artery were acquired using 7T-MRI. Seven control rats and 16 rats with right endothelial injury (VED) were used. For five of the VED models where blood flow in both the right and left common carotid arteries was confirmed, 4D-flow MRI was performed after obtaining 3D images using the time of flight method. MRI was performed to calculate the flow velocity, flow rate, WSS, and cross-sectional area of the proximal, middle, and distal carotid arteries. In all five VED models, blood flow rate and WSS were predominantly decreased at the proximal injured side compared to the ipsilateral control side (<i>p</i> &lt; 0.05). The cross-sectional area of the vessel distal to the injured side of the VED model was reduced compared to that of the non-injured side (<i>p</i> &lt; 0.05). A comparison of the proximal part of the uninjured side between the control group and VED model showed that the vascular cross-sectional area was predominantly increased in the VED model (<i>p</i> &lt; 0.05). 4D-flow MRI with 7T-MRI enabled analysis of changes in flow velocity, flow rate, WSS, and cross-sectional area due to vascular endothelial injury.</p>

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In-vivo assessment of vascular endothelial injury in a rat model of unilateral carotid artery injury using 4D-flow MRI

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月27日

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  • Sei Yasuda,
  • Natsuo Banura,
  • Mako Ito,
  • Kazuma Bono,
  • Reika Sawaya,
  • Junpei Ueda,
  • Shigeyoshi Saito

摘要

Herein, 4D-flow MRI was performed on the bilateral carotid arteries in a rat model of unilateral carotid artery injury to analyze changes in flow velocity, flow rate, wall shear stress (WSS), and cross-sectional area due to endothelial injury. MR images of the rat carotid artery were acquired using 7T-MRI. Seven control rats and 16 rats with right endothelial injury (VED) were used. For five of the VED models where blood flow in both the right and left common carotid arteries was confirmed, 4D-flow MRI was performed after obtaining 3D images using the time of flight method. MRI was performed to calculate the flow velocity, flow rate, WSS, and cross-sectional area of the proximal, middle, and distal carotid arteries. In all five VED models, blood flow rate and WSS were predominantly decreased at the proximal injured side compared to the ipsilateral control side (p < 0.05). The cross-sectional area of the vessel distal to the injured side of the VED model was reduced compared to that of the non-injured side (p < 0.05). A comparison of the proximal part of the uninjured side between the control group and VED model showed that the vascular cross-sectional area was predominantly increased in the VED model (p < 0.05). 4D-flow MRI with 7T-MRI enabled analysis of changes in flow velocity, flow rate, WSS, and cross-sectional area due to vascular endothelial injury.