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<p>Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, <sup>1</sup>HNMR, TGA/DTA and densitometer techniques. Then, it was used as a novel and capable catalyst for the green synthesis of thiazolo[3,2-<i>a</i>]pyrimidines via a one-pot four-component condensation reaction of 4-hydroxycoumarin, 2-amino-6-methylbenzothiazole, morpholine, and aldehydes at 80&#xa0;°C with high yield and short reaction time.</p>

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Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines

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  • 发表日期：

    2025年5月31日

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  • Nastaran Dehnokhalaji,
  • Davood Habibi,
  • Arezo Monem,
  • Afagh Ranjbaran

摘要

Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, 1HNMR, TGA/DTA and densitometer techniques. Then, it was used as a novel and capable catalyst for the green synthesis of thiazolo[3,2-a]pyrimidines via a one-pot four-component condensation reaction of 4-hydroxycoumarin, 2-amino-6-methylbenzothiazole, morpholine, and aldehydes at 80 °C with high yield and short reaction time.