Scholarlink

<p>The expression of TIMM8A, a molecular chaperone involved in mitochondrial protein translocation, was observed to be significantly elevated in various tumor types. However, the specific role of TIMM8A in cancer development and its underlying molecular mechanism remains inadequately understood. In this study, our primary objective was to investigate the functional implications of TIMM8A in breast cancer development, while also assessing its expression levels and prognostic relevance in pan-cancer. Notably, TIMM8A exhibited high expression in nearly 33 different cancer types, which was consistently associated with unfavorable clinical outcomes. In breast cancer, TIMM8A exhibited a strong association with prognosis and demonstrated its potential as an independent prognostic indicator. Additionally, the inhibition of TIMM8A effectively impeded the proliferation of MCF-7 and MDA-MB-231 cells, while also suppressing their migratory and invasive capabilities in vitro. Mechanistically, the downregulation of NF-κB p65, upregulation of pro-apoptotic proteins, and regulation of EMT-related proteins were observed upon TIMM8A knockdown. Furthermore, the over-expression of miR-10b-5p effectively hindered the expression of TIMM8A. Collectively, TIMM8A, a critical oncogene, was regulated by miR-10b-5p and could activate NF-κB signaling cascade response, promote apoptosis inhibition and regulate EMT-related protein expression, thereby stimulating proliferation, migration, and invasion of breast cancer cells.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月26日

查看全文
  • Weiwei Wang,
  • Mengjie Liu,
  • Huizi Wu,
  • Jia Li,
  • Wei Lv,
  • Chaofan Li,
  • Chong Du,
  • Cong Feng,
  • Yu Zhang,
  • Yifan Cai,
  • Yiwei Jia,
  • Yijian Hu,
  • Jingkun Qu,
  • Shuqun Zhang,
  • Fei Wu

摘要

The expression of TIMM8A, a molecular chaperone involved in mitochondrial protein translocation, was observed to be significantly elevated in various tumor types. However, the specific role of TIMM8A in cancer development and its underlying molecular mechanism remains inadequately understood. In this study, our primary objective was to investigate the functional implications of TIMM8A in breast cancer development, while also assessing its expression levels and prognostic relevance in pan-cancer. Notably, TIMM8A exhibited high expression in nearly 33 different cancer types, which was consistently associated with unfavorable clinical outcomes. In breast cancer, TIMM8A exhibited a strong association with prognosis and demonstrated its potential as an independent prognostic indicator. Additionally, the inhibition of TIMM8A effectively impeded the proliferation of MCF-7 and MDA-MB-231 cells, while also suppressing their migratory and invasive capabilities in vitro. Mechanistically, the downregulation of NF-κB p65, upregulation of pro-apoptotic proteins, and regulation of EMT-related proteins were observed upon TIMM8A knockdown. Furthermore, the over-expression of miR-10b-5p effectively hindered the expression of TIMM8A. Collectively, TIMM8A, a critical oncogene, was regulated by miR-10b-5p and could activate NF-κB signaling cascade response, promote apoptosis inhibition and regulate EMT-related protein expression, thereby stimulating proliferation, migration, and invasion of breast cancer cells.