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<p>This study evaluated the clinical utility of C-reactive protein (CRP) and homocysteine (Hcy) as biomarkers for injury severity assessment and prognostic prediction in traumatic brain injury (TBI). A retrospective cohort study included 103 TBI patients (February 2020 to February 2023) stratified by Glasgow Coma Scale (GCS) scores into mild (<i>n</i> = 20), moderate (<i>n</i> = 32), and severe (<i>n</i> = 51) injury groups, alongside 20 healthy controls. Serum and cerebrospinal fluid (CSF) CRP and Hcy levels were measured serially over 14 days post-injury. Prognostic outcomes were assessed using 3-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) scores. Severe TBI patients exhibited significantly higher serum and CSF CRP levels than moderate/mild groups (<i>p</i> &lt; 0.01), peaking within 72&#xa0;h and remaining elevated through day 14. Serum Hcy levels increased rapidly post-injury, with severe cases sustaining prolonged elevations (&gt; 7 days vs. ≤3 days in mild/moderate groups). CRP and Hcy levels inversely correlated with admission GCS scores (<i>r</i> = − 0.756, 0.756 and − 0.652, respectively; <i>p</i> &lt; 0.001) and positively correlated with intracranial pressure (<i>r</i> = 0.829, 0.779 and 0.633). The initial CRP and Hcy levels were negatively correlated with GOS and positively correlated with mRS at 3 months post-injury, indicating their potential as biomarkers for assessing injury severity and predicting prognosis in TBI patients. CRP (serum/CSF) and serum Hcy are reliable biomarkers for assessing injury severity and predicting prognosis in TBI patients.</p>

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Elevation of C-reactive protein and homocysteine levels as reliable biomarkers for assessing injury severity and prognosis in traumatic brain injury

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月29日

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  • Zi-Yan Wang,
  • Wei Du,
  • Xian-Zhi Liu,
  • Yuan Li,
  • Jun Liu

摘要

This study evaluated the clinical utility of C-reactive protein (CRP) and homocysteine (Hcy) as biomarkers for injury severity assessment and prognostic prediction in traumatic brain injury (TBI). A retrospective cohort study included 103 TBI patients (February 2020 to February 2023) stratified by Glasgow Coma Scale (GCS) scores into mild (n = 20), moderate (n = 32), and severe (n = 51) injury groups, alongside 20 healthy controls. Serum and cerebrospinal fluid (CSF) CRP and Hcy levels were measured serially over 14 days post-injury. Prognostic outcomes were assessed using 3-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) scores. Severe TBI patients exhibited significantly higher serum and CSF CRP levels than moderate/mild groups (p < 0.01), peaking within 72 h and remaining elevated through day 14. Serum Hcy levels increased rapidly post-injury, with severe cases sustaining prolonged elevations (> 7 days vs. ≤3 days in mild/moderate groups). CRP and Hcy levels inversely correlated with admission GCS scores (r = − 0.756, 0.756 and − 0.652, respectively; p < 0.001) and positively correlated with intracranial pressure (r = 0.829, 0.779 and 0.633). The initial CRP and Hcy levels were negatively correlated with GOS and positively correlated with mRS at 3 months post-injury, indicating their potential as biomarkers for assessing injury severity and predicting prognosis in TBI patients. CRP (serum/CSF) and serum Hcy are reliable biomarkers for assessing injury severity and predicting prognosis in TBI patients.