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<p>To determine whether cardiac sympathetic nervous dysfunction is present, in this single center prospective, non-randomized trial non-invasive SPECT/CT imaging using the radiotracer <sup>123</sup>I-metaiodobenzylguanidine was performed in 33 recovered COVID-19 patients without pre-existing cardiac conditions. Increased cardiac sympathetic activity, as indicated by late HMR, was observed in 67.7% of patients. At 6–8&#xa0;months, 82% of these subjects (27/33) received follow-up, and cardiac sympathetic innervation abnormalities were still present in 70.4% (19/27). Additionally, at 12–15&#xa0;months post-diagnosis, persistently abnormal HMRs were found in 9 individuals who initially had abnormal sympathetic innervation. Further follow-up is needed to investigate potential long-term cardiovascular consequences of COVID-19.</p>

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Cardiac risk in recovered Covid-19 patients evaluated by 123I-mIBG

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月23日

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  • Alessandro Liebich,
  • Gabriel Sheikh,
  • Ralph. A. Bundschuh,
  • Malte Kircher,
  • Alexander Dierks,
  • Bernd Nittbaur,
  • Philip Raake,
  • Maximilian Rieger,
  • Takahiro Higuchi,
  • Christian H. Pfob,
  • Constantin Lapa

摘要

To determine whether cardiac sympathetic nervous dysfunction is present, in this single center prospective, non-randomized trial non-invasive SPECT/CT imaging using the radiotracer 123I-metaiodobenzylguanidine was performed in 33 recovered COVID-19 patients without pre-existing cardiac conditions. Increased cardiac sympathetic activity, as indicated by late HMR, was observed in 67.7% of patients. At 6–8 months, 82% of these subjects (27/33) received follow-up, and cardiac sympathetic innervation abnormalities were still present in 70.4% (19/27). Additionally, at 12–15 months post-diagnosis, persistently abnormal HMRs were found in 9 individuals who initially had abnormal sympathetic innervation. Further follow-up is needed to investigate potential long-term cardiovascular consequences of COVID-19.