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<p>Titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) are extensively incorporated in numerous industrial products. Adult male Albino rats received oral TiO<sub>2</sub> NPs at a dose of 150&#xa0;mg/kg body weight for 14 days exhibited both hepatic and renal toxicities manifested by disruption in serum hepatic and renal biomarkers, imbalance in oxidative-antioxidant system, up-regulation of mRNA expression of genes encode inflammation (IL-1β, TNF-α) and apoptosis (Caspase-3, BAX) with down-regulation of PCNA immune-staining density and histological modifications in hepatic and renal architecture. Carboxymethyl chitosan (5&#xa0;mg/kg BW) significantly improved the harmful effects of nano-titanium particles highlighting its relevance in reducing TiO<sub>2</sub> NPs – induced hepatic and renal dysfunction.</p>

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Chitosan attenuates titanium dioxide nanoparticles induced hepatic and renal toxicities

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月30日

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  • Amal Abdelmonem Halawa,
  • Gehad Elshopakey,
  • Mohamed El-Adl,
  • Samah Lashen,
  • Nancy Shalaby,
  • Shaymaa Rezk,
  • Omar Elmetwally,
  • Ehab Eldomany,
  • Ahmed Farghali,
  • Mohamed Elmetwally

摘要

Titanium dioxide nanoparticles (TiO2 NPs) are extensively incorporated in numerous industrial products. Adult male Albino rats received oral TiO2 NPs at a dose of 150 mg/kg body weight for 14 days exhibited both hepatic and renal toxicities manifested by disruption in serum hepatic and renal biomarkers, imbalance in oxidative-antioxidant system, up-regulation of mRNA expression of genes encode inflammation (IL-1β, TNF-α) and apoptosis (Caspase-3, BAX) with down-regulation of PCNA immune-staining density and histological modifications in hepatic and renal architecture. Carboxymethyl chitosan (5 mg/kg BW) significantly improved the harmful effects of nano-titanium particles highlighting its relevance in reducing TiO2 NPs – induced hepatic and renal dysfunction.