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<p>Quantitative strain elastography (SE), referred to as E-Cervix (Samsung Medison), is a novel method for assessing parameters that indirectly describe the elasticity of the cervix. This evaluation yields quantitative parameters based on the analysis of the elastographic map image, which represents a new approach in the context of SE. In our study, we aimed to examine the reproducibility of this method in evaluating the cervix of non-pregnant women, the impact of basic demographic parameters of the patient on the results, and the responsiveness of the method, i.e., the assessment of changes occurring in the results after the vaginal application of a 400&#xa0;µg dose of misoprostol. We included 80 patients scheduled for hysteroscopy who underwent elastographic examination using the E-Cervix module. The examination was performed twice upon admission to the department by the same ultrasonographer and then again 10–12&#xa0;h after vaginal application of misoprostol, consecutively by two ultrasonographers. Our study demonstrated high reproducibility of all obtained parameters, with ICC (Intraclass Correlation Coefficient) for intraobserver variability being good to excellent, ranging from 0.85 for ECI (Elasticity index) to 0.94 for IOS (Internal Os strain)/EOS (External Os strain) ratio. For interobserver variability, ICC values ranged from 0.76 for ECI to 0.97 for IOS/EOS ratio. We observed no significant correlation between parameters such as height, weight, BMI (body mass index), and the number of births in the patient’s history and the values of elastographic parameters. We found weak to moderate positive correlations between the day of the cycle in which the patient was and ECI (rho = 0.28), EOS (rho = 0.41), IOS/EOS ratio (rho = 0.33). The study observed a significant increase in the median value of the HR (Hardness ratio) parameter after the application of vaginal misoprostol (median difference = 5.32), an increase in EOS (difference of the medians = 0.04), and a significant decrease in IOS/EOS ratio (difference of medians = −&#xa0;0.05). In our study, we demonstrated high reproducibility and repeatability of E-Cervix parameters in non-pregnant women and showed a negligible influence of most demographic factors on the study outcomes, as well as changes in parameter values under the influence of drugs affecting cervical elasticity. The method appears to be suitable for evaluating the cervix in non-pregnant women.</p>

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Reproducibility of quantitative cervical strain elastography in nonpregnant patients and the effect of vaginal misoprostol on measured parameters

  • 期刊论文

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  • 发表日期：

    2025年5月15日

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  • Jakub Mlodawski,
  • Justyna Plusajska,
  • Karolina Detka,
  • Grzegorz Swiercz,
  • Marta Mlodawska

摘要

Quantitative strain elastography (SE), referred to as E-Cervix (Samsung Medison), is a novel method for assessing parameters that indirectly describe the elasticity of the cervix. This evaluation yields quantitative parameters based on the analysis of the elastographic map image, which represents a new approach in the context of SE. In our study, we aimed to examine the reproducibility of this method in evaluating the cervix of non-pregnant women, the impact of basic demographic parameters of the patient on the results, and the responsiveness of the method, i.e., the assessment of changes occurring in the results after the vaginal application of a 400 µg dose of misoprostol. We included 80 patients scheduled for hysteroscopy who underwent elastographic examination using the E-Cervix module. The examination was performed twice upon admission to the department by the same ultrasonographer and then again 10–12 h after vaginal application of misoprostol, consecutively by two ultrasonographers. Our study demonstrated high reproducibility of all obtained parameters, with ICC (Intraclass Correlation Coefficient) for intraobserver variability being good to excellent, ranging from 0.85 for ECI (Elasticity index) to 0.94 for IOS (Internal Os strain)/EOS (External Os strain) ratio. For interobserver variability, ICC values ranged from 0.76 for ECI to 0.97 for IOS/EOS ratio. We observed no significant correlation between parameters such as height, weight, BMI (body mass index), and the number of births in the patient’s history and the values of elastographic parameters. We found weak to moderate positive correlations between the day of the cycle in which the patient was and ECI (rho = 0.28), EOS (rho = 0.41), IOS/EOS ratio (rho = 0.33). The study observed a significant increase in the median value of the HR (Hardness ratio) parameter after the application of vaginal misoprostol (median difference = 5.32), an increase in EOS (difference of the medians = 0.04), and a significant decrease in IOS/EOS ratio (difference of medians = − 0.05). In our study, we demonstrated high reproducibility and repeatability of E-Cervix parameters in non-pregnant women and showed a negligible influence of most demographic factors on the study outcomes, as well as changes in parameter values under the influence of drugs affecting cervical elasticity. The method appears to be suitable for evaluating the cervix in non-pregnant women.