<p>A key innovation of this study is the first-ever experimental determination of the ratio of permanent to total differential pressure loss (Δp_loss/Δp) for a segmented orifice with an inclined inflow plane—a geometry not standardized in any current measurement norms. While previous investigations by the authors focused on flow characteristics, this paper uniquely quantifies energy-related pressure losses, showing that a 60° inclination reduces permanent pressure loss by up to 4.9% compared to conventional 90° orifices. A combined experimental and numerical approach was applied to evaluate three orifice geometries with water as the working fluid. CFD simulations using the Transition SST model guided the optimization of pressure tapping locations. The results indicate that the inclined design improves flow stability and measurement reliability while reducing pressure losses. The findings suggest that the segmented inclined orifice is a cost-effective and energy-efficient alternative to conventional differential pressure flowmeters in industrial applications.</p>