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<p>This study presents an efficient and sustainable method for the synthesis of novel spiro[chromeno[2,3-<i>d</i>][1,3,4]thiadiazolo[3,2-<i>a</i>]pyrimidine-10,3′-indoline]-2′,9,11-trione derivatives via a three-component condensation reaction is introduced. The reaction involves dimedone, 5<i>H</i>-[1,3,4]thiadiazolo[3,2-<i>a</i>]pyrimidine-5,7(6&#xa0;H)-dione, and isatin derivatives, catalyzed by the economical and highly effective Keggin heteropolyacid (H₃PW₁₂O₄₀). This protocol achieves (70–90%) yields within relatively short reaction times under mild and solvent-free conditions. Using a green, cost-effective catalyst highlights the method’s practicality and potential for broader applications in synthetic organic chemistry, offering an attractive route for spiro oxindole derivative synthesis.</p>

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Synthesis of novel spiro[chromeno[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines via an isatin-based three-component reaction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月12日

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  • Maryam Khalili,
  • Abbas Ali Esmaeili

摘要

This study presents an efficient and sustainable method for the synthesis of novel spiro[chromeno[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidine-10,3′-indoline]-2′,9,11-trione derivatives via a three-component condensation reaction is introduced. The reaction involves dimedone, 5H-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5,7(6 H)-dione, and isatin derivatives, catalyzed by the economical and highly effective Keggin heteropolyacid (H₃PW₁₂O₄₀). This protocol achieves (70–90%) yields within relatively short reaction times under mild and solvent-free conditions. Using a green, cost-effective catalyst highlights the method’s practicality and potential for broader applications in synthetic organic chemistry, offering an attractive route for spiro oxindole derivative synthesis.