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<p><i>Acanthopagrus latus</i> is native to the Indo-West Pacific region. It also inhabits waters from the East China Sea to South China Sea, ranking among the common nearshore fish species. This species holds substantial aquaculture potential, and serves as an ideal model for studying the euryhaline evolutionary mechanisms of sparid fishes. Here, the first near telomere-to-telomere (near T2T) chromosome-scale genome assembly of <i>A. latus</i> was generated using a combination of PacBio HiFi, Nanopore ONT ultra-long reads and chromatin conformation capture technology (Hi-C). This assembled genome is approximately 693.4 Mb in total, with a contig N50 of 31.0 Mb. It has been anchored into 24 chromosomes, including entire 48 telomeres. Within this near T2T genome, about 177.1 Mb of repetitive sequences were identified, and 28,595 protein-coding genes were annotated. The BUSCO analysis confirmed this genome and gene completeness at 98.9% and 98.3%. This new genome assembly provides a valuable reference for further research into the evolutionary mechanisms of osmoregulation in sparid fishes and euryhalinity in teleosts. We also offer high-quality genomic resources to address various challenges in the aquaculture of <i>A. latus</i>.</p>

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A near telomere-to-telomere chromosome-scale genome assembly of yellowfin seabream, Acanthopagrus latus (Houttuyn, 1782)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月24日

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  • Kecheng Zhu,
  • Guangwen Lai,
  • Huayang Guo,
  • Baosuo Liu,
  • Nan Zhang,
  • Lin Xian,
  • Tengfei Zhu,
  • Chao Bian,
  • Dianchang Zhang

摘要

Acanthopagrus latus is native to the Indo-West Pacific region. It also inhabits waters from the East China Sea to South China Sea, ranking among the common nearshore fish species. This species holds substantial aquaculture potential, and serves as an ideal model for studying the euryhaline evolutionary mechanisms of sparid fishes. Here, the first near telomere-to-telomere (near T2T) chromosome-scale genome assembly of A. latus was generated using a combination of PacBio HiFi, Nanopore ONT ultra-long reads and chromatin conformation capture technology (Hi-C). This assembled genome is approximately 693.4 Mb in total, with a contig N50 of 31.0 Mb. It has been anchored into 24 chromosomes, including entire 48 telomeres. Within this near T2T genome, about 177.1 Mb of repetitive sequences were identified, and 28,595 protein-coding genes were annotated. The BUSCO analysis confirmed this genome and gene completeness at 98.9% and 98.3%. This new genome assembly provides a valuable reference for further research into the evolutionary mechanisms of osmoregulation in sparid fishes and euryhalinity in teleosts. We also offer high-quality genomic resources to address various challenges in the aquaculture of A. latus.