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<p>The barbel steed (<i>Hemibarbus labeo</i>), an economically important freshwater fish in China, belongs to the order Cypriniformes and the family Cyprinidae. At present, research has been conducted on the basic biology, artificial breeding, aquaculture, and nutritional requirements of <i>H. labeo</i>. However, genome assembly and exploration of the unique genomic composition of the barbel steed are still in their infancy. Previously available genome assemblies were fragmented and incomplete, hindering advances in genomic research and breeding applications. In this study, we generated a near complete telomere-to-telomere (T2T) genome assemblies for a male <i>H. labeo</i> using PacBio HiFi, ONT ultra-long, and Hi-C data. The resulting assemblies span 1,040.46 Mb with contig N50 of 41.15 Mb, and 25 chromosomes were assembled. The quality value (QV) scores were 60.02, and Benchmarking Universal Single-Copy Orthologs (BUSCO) completeness scores were 98.3%. The genome contains a total of 37,023 coding genes, of which 35,589 (96.13%) were functionally annotated. The high-quality near-T2T assemblies provide invaluable resources for molecular breeding and advancing biological and evolutionary research in <i>H. labeo</i>.</p>

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Near-complete telomere-to-telomere genome assembly of a male barbel steed (Hemibarbus labeo)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月6日

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  • Wei Liu,
  • Ming Qi,
  • Wenrui Shi,
  • Xiaofeng Zhang,
  • Gaohua Yao,
  • Qinghui Meng,
  • Chen Chen,
  • Tianlun Zheng,
  • Yongyi Jia

摘要

The barbel steed (Hemibarbus labeo), an economically important freshwater fish in China, belongs to the order Cypriniformes and the family Cyprinidae. At present, research has been conducted on the basic biology, artificial breeding, aquaculture, and nutritional requirements of H. labeo. However, genome assembly and exploration of the unique genomic composition of the barbel steed are still in their infancy. Previously available genome assemblies were fragmented and incomplete, hindering advances in genomic research and breeding applications. In this study, we generated a near complete telomere-to-telomere (T2T) genome assemblies for a male H. labeo using PacBio HiFi, ONT ultra-long, and Hi-C data. The resulting assemblies span 1,040.46 Mb with contig N50 of 41.15 Mb, and 25 chromosomes were assembled. The quality value (QV) scores were 60.02, and Benchmarking Universal Single-Copy Orthologs (BUSCO) completeness scores were 98.3%. The genome contains a total of 37,023 coding genes, of which 35,589 (96.13%) were functionally annotated. The high-quality near-T2T assemblies provide invaluable resources for molecular breeding and advancing biological and evolutionary research in H. labeo.