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<p>The lacrimal gland is a major exocrine organ responsible for tear secretion and is essential for maintaining ocular surface homeostasis. However, time-resolved transcriptomic resources for this tissue remain limited. Here, we generated a bulk RNA-seq time-series dataset from extraorbital lacrimal glands of male C57BL/6 J mice maintained under a controlled 12:12 light-dark schedule. Tissue samples were collected at 3-h intervals across a 24-h cycle, yielding eight time points with three biological replicates per time point. Libraries were prepared from total RNA and sequenced as 150-bp paired-end reads. This dataset provides a reusable temporal transcriptomic resource for downstream studies of lacrimal gland biology, ocular surface physiology, and gene-expression dynamics under defined light-dark conditions.</p>

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A 24-hour light-dark time-series bulk RNA-seq dataset of the mouse lacrimal gland

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月27日

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  • Hongyu Li,
  • Ting Wang,
  • Chuyao Wang,
  • Aijun Deng,
  • Xinwei Jiao

摘要

The lacrimal gland is a major exocrine organ responsible for tear secretion and is essential for maintaining ocular surface homeostasis. However, time-resolved transcriptomic resources for this tissue remain limited. Here, we generated a bulk RNA-seq time-series dataset from extraorbital lacrimal glands of male C57BL/6 J mice maintained under a controlled 12:12 light-dark schedule. Tissue samples were collected at 3-h intervals across a 24-h cycle, yielding eight time points with three biological replicates per time point. Libraries were prepared from total RNA and sequenced as 150-bp paired-end reads. This dataset provides a reusable temporal transcriptomic resource for downstream studies of lacrimal gland biology, ocular surface physiology, and gene-expression dynamics under defined light-dark conditions.