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<p><i>Anisodus tanguticus</i> (Maxim.) Pascher (<i>A. tanguticus</i>), a cold-tolerant perennial herb in the Solanaceae family, is distributed across China’s Qinghai-Tibet Plateau and extends to Nepal, Bhutan, Sikkim, and India. As a Tibetan medicinal plant, it is used to treat pain, ulcers, etc.; its roots yield antispasmodic and anesthetic compounds, and other parts are used as a feed additive for yaks to enhance cold resistance in northwest Sichuan. In this study, samples were collected from Seda County (northwestern Sichuan, China) for sequencing. Using PacBio HiFi sequencing and Hi-C scaffolding, a high-quality chromosome-scale genome assembly was generated, with a genome size of 1599.64 Mb, a scaffold N50 of 62.01 Mb, and a contig N50 of 38.51 Mb. A total of 24 superscaffolds (93.65% of the genome) were anchored to 24 chromosomes. Compared with previously reported assemblies of <i>A. tanguticus</i> and <i>A. acutangulus</i>, this assembly shows improved scaffold length and completeness. Genome annotation identified 64.95% repetitive elements and 45,930 protein-coding genes, and comparative analysis of four <i>Anisodus</i> genomes revealed conserved patterns of gene density, GC content, LTR, and LINE elements. This study provides the first high-quality chromosome-scale genome resource of <i>A. tanguticus</i> from the Qinghai-Tibet Plateau, supporting studies on phylogeny, genetic diversity, and breeding, as well as further exploration of its genomic basis of high-altitude adaptation.</p>

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A chromosome-level genome assembly of SAGS Anisodus tanguticus (Maxim.) Pascher (Solanaceae) from the Tibetan region of Sichuan, China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月24日

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  • Gang Liu,
  • Dan Su,
  • Yutong Liu,
  • Zhan Shi,
  • Shenzhong Gao,
  • Xin He,
  • Shiyin Zhang,
  • Heng Deng,
  • Jingjing Xiao,
  • Yinan Yao,
  • Peng Shu

摘要

Anisodus tanguticus (Maxim.) Pascher (A. tanguticus), a cold-tolerant perennial herb in the Solanaceae family, is distributed across China’s Qinghai-Tibet Plateau and extends to Nepal, Bhutan, Sikkim, and India. As a Tibetan medicinal plant, it is used to treat pain, ulcers, etc.; its roots yield antispasmodic and anesthetic compounds, and other parts are used as a feed additive for yaks to enhance cold resistance in northwest Sichuan. In this study, samples were collected from Seda County (northwestern Sichuan, China) for sequencing. Using PacBio HiFi sequencing and Hi-C scaffolding, a high-quality chromosome-scale genome assembly was generated, with a genome size of 1599.64 Mb, a scaffold N50 of 62.01 Mb, and a contig N50 of 38.51 Mb. A total of 24 superscaffolds (93.65% of the genome) were anchored to 24 chromosomes. Compared with previously reported assemblies of A. tanguticus and A. acutangulus, this assembly shows improved scaffold length and completeness. Genome annotation identified 64.95% repetitive elements and 45,930 protein-coding genes, and comparative analysis of four Anisodus genomes revealed conserved patterns of gene density, GC content, LTR, and LINE elements. This study provides the first high-quality chromosome-scale genome resource of A. tanguticus from the Qinghai-Tibet Plateau, supporting studies on phylogeny, genetic diversity, and breeding, as well as further exploration of its genomic basis of high-altitude adaptation.