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<p>Colorectal cancer (CRC) is the third most prevalent cancer type worldwide. Despite improvements in screening programs, the incidence of early-onset CRC (EOCRC) in patients under 50 years old is rapidly increasing, including in Korea, in contrast to the decreasing trend of late-onset CRC (LOCRC). However, a comprehensive biological understanding of CRC’s coding and non-coding variants, onset-dependent prognostic variables, and the genetic and transcriptomic differences between EOCRC and LOCRC remains limited. To provide insights into this, we present a high-quality multi-omics dataset consisting of whole genome sequencing (WGS) and RNA sequencing (RNA-seq) data from 49 EOCRC and 50 LOCRC patients. WGS was performed using the DNBSEQ-T7 platform, generating 1.409 billion reads at an average depth of 37.70×. RNA-seq data previously generated from the same samples are included to support integrative analysis. This dataset enables comprehensive exploration of genomic and transcriptomic alterations in CRC and serves as a valuable resource for identifying onset-specific biomarkers and molecular features, ultimately supporting improved diagnosis and therapeutic strategies.</p>

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Whole genome sequencing data of early- and late-onset colorectal cancer in 99 Korean patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月8日

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  • Jae-Yoon Kim,
  • Ye Jin Ha,
  • Seung-Jin Park,
  • Sun-Woo Lee,
  • Seon-Yeop Kim,
  • Seung-Eun Oh,
  • Jong-Lyul Park,
  • Ka Hee Tak,
  • Yong Sik Yoon,
  • Jong Lyul Lee,
  • Seon-Young Kim,
  • Chan Wook Kim

摘要

Colorectal cancer (CRC) is the third most prevalent cancer type worldwide. Despite improvements in screening programs, the incidence of early-onset CRC (EOCRC) in patients under 50 years old is rapidly increasing, including in Korea, in contrast to the decreasing trend of late-onset CRC (LOCRC). However, a comprehensive biological understanding of CRC’s coding and non-coding variants, onset-dependent prognostic variables, and the genetic and transcriptomic differences between EOCRC and LOCRC remains limited. To provide insights into this, we present a high-quality multi-omics dataset consisting of whole genome sequencing (WGS) and RNA sequencing (RNA-seq) data from 49 EOCRC and 50 LOCRC patients. WGS was performed using the DNBSEQ-T7 platform, generating 1.409 billion reads at an average depth of 37.70×. RNA-seq data previously generated from the same samples are included to support integrative analysis. This dataset enables comprehensive exploration of genomic and transcriptomic alterations in CRC and serves as a valuable resource for identifying onset-specific biomarkers and molecular features, ultimately supporting improved diagnosis and therapeutic strategies.