Scholarlink

<p>Studies have reported diverse functions of immune cells in response against the transplanted kidney, highlighting their significant roles in immunosuppressive response. Peripheral blood analyses showed differences in immune cell composition between kidney transplant recipients and healthy donors, however, the differences in peripheral blood immune landscape between patients with different rejection types and treatment phases remain unclear. Here, we present a single-cell RNA sequencing (scRNA-seq) dataset of peripheral blood cells derived from five participants after kidney transplantation. The dataset comprises 98,595 quality-control passed cells along with clinical metadata, enabling a comparative analysis of immune cell populations before and after immunosuppression treatment as well as between different rejection types. We preliminarily identified major cell types including immune and non-immune cells, and further annotated the immune cell subsets. This transcriptomic data will serve as a resource to explore new cellular biomarkers and microenvironmental changes in peripheral blood of kidney recipients with different reaction types, and to deepen our insights into the role of immunosuppression treatment on graft rejection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

ScRNA profiling of peripheral blood in kidney transplant recipients across rejection responses and treatments

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月24日

查看全文
  • Dan Wu,
  • Jia You,
  • Hongxia Liu,
  • Kaile Zheng,
  • Yan Zhu,
  • Na Zeng,
  • Hong Sun,
  • Xuebin Wang

摘要

Studies have reported diverse functions of immune cells in response against the transplanted kidney, highlighting their significant roles in immunosuppressive response. Peripheral blood analyses showed differences in immune cell composition between kidney transplant recipients and healthy donors, however, the differences in peripheral blood immune landscape between patients with different rejection types and treatment phases remain unclear. Here, we present a single-cell RNA sequencing (scRNA-seq) dataset of peripheral blood cells derived from five participants after kidney transplantation. The dataset comprises 98,595 quality-control passed cells along with clinical metadata, enabling a comparative analysis of immune cell populations before and after immunosuppression treatment as well as between different rejection types. We preliminarily identified major cell types including immune and non-immune cells, and further annotated the immune cell subsets. This transcriptomic data will serve as a resource to explore new cellular biomarkers and microenvironmental changes in peripheral blood of kidney recipients with different reaction types, and to deepen our insights into the role of immunosuppression treatment on graft rejection.