Scholarlink

<p><i>Trichomonas</i> vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, the most prevalent non-viral sexually transmitted infection, with significant impact on public health and economy. Here, we present a chromosome-level genome of <i>T. vaginalis</i> strain IR-78 (ATCC 50138), assembled using short and long-read sequencing technologies as well as chromatin conformation capture sequencing (Hi-C). The assembled genome is 173.3 Mb in size, with an N50 scaffold length of 26.4 Mb. The assembly is anchored in six super-scaffolds, corresponding to the six chromosomes of <i>T. vaginalis</i>, covering 93.5% of the genome. A total of 43,326 protein-coding genes were predicted, of which 95.4% were annotated using multiple databases, including Gene Ontology, eggNOG, and KEGG. Among these, 16,656 genes encoded hypothetical proteins. This high-quality genome assembly provides an additional resource for ongoing research on <i>T. vaginalis</i> pathogenesis, drug resistance, and host-parasite interactions. It furthermore enables comparative genomic studies to assess genomic variety across different <i>Trichomonas</i> species.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Chromosome-level genome assembly of Trichomonas vaginalis strain IR-78 (ATCC 50138)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月5日

查看全文
  • Mostafa Y. Abdel-Glil,
  • Johannes Solle,
  • Heinrich Neubauer,
  • Lisa D. Sprague

摘要

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, the most prevalent non-viral sexually transmitted infection, with significant impact on public health and economy. Here, we present a chromosome-level genome of T. vaginalis strain IR-78 (ATCC 50138), assembled using short and long-read sequencing technologies as well as chromatin conformation capture sequencing (Hi-C). The assembled genome is 173.3 Mb in size, with an N50 scaffold length of 26.4 Mb. The assembly is anchored in six super-scaffolds, corresponding to the six chromosomes of T. vaginalis, covering 93.5% of the genome. A total of 43,326 protein-coding genes were predicted, of which 95.4% were annotated using multiple databases, including Gene Ontology, eggNOG, and KEGG. Among these, 16,656 genes encoded hypothetical proteins. This high-quality genome assembly provides an additional resource for ongoing research on T. vaginalis pathogenesis, drug resistance, and host-parasite interactions. It furthermore enables comparative genomic studies to assess genomic variety across different Trichomonas species.