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<p>Neuroimaging and cognitive neuroscience studies have identified neural circuits linked to anxiety, mood, and trauma-related symptoms and focused on their interaction with the medial prefrontal default mode circuitry. Despite these advances, developing new neuromodulatory treatments based on neurocircuitry remains challenging. It remains unclear which nodes within and controlling these circuits are affected and how their impairment is connected to psychiatric symptoms. Concurrent single-pulse (sp) TMS/fMRI offers a promising approach to probing and mapping the integrity of these circuits. In this study, we present concurrent spTMS/fMRI data along with structural MRI scans from 152 participants, across 4 clinical groupings: Non-trauma Exposed Healthy Controls (NTHC; n = 46), Trauma Exposed Healthy Controls (TEHC; n = 29), Non-trauma Induced Symptomatic (NTS; n = 43), Trauma Induced Symptomatic (NIS; n = 34).The spTMS was administered to 11 different cortical sites, providing a dataset that allows researchers to investigate how brain circuits are modulated by spTMS.</p>

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Concurrent single-pulse TMS-fMRI dataset to reveal the causal connectome in healthy and patient populations

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

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  • Cameron Glick,
  • Niharika Gajawelli,
  • Yinming Sun,
  • Faizan Badami,
  • Manish Saggar,
  • Amit Etkin

摘要

Neuroimaging and cognitive neuroscience studies have identified neural circuits linked to anxiety, mood, and trauma-related symptoms and focused on their interaction with the medial prefrontal default mode circuitry. Despite these advances, developing new neuromodulatory treatments based on neurocircuitry remains challenging. It remains unclear which nodes within and controlling these circuits are affected and how their impairment is connected to psychiatric symptoms. Concurrent single-pulse (sp) TMS/fMRI offers a promising approach to probing and mapping the integrity of these circuits. In this study, we present concurrent spTMS/fMRI data along with structural MRI scans from 152 participants, across 4 clinical groupings: Non-trauma Exposed Healthy Controls (NTHC; n = 46), Trauma Exposed Healthy Controls (TEHC; n = 29), Non-trauma Induced Symptomatic (NTS; n = 43), Trauma Induced Symptomatic (NIS; n = 34).The spTMS was administered to 11 different cortical sites, providing a dataset that allows researchers to investigate how brain circuits are modulated by spTMS.