Scholarlink

<p>Myelin sheaths comprise compacted layers of membrane wrapped around axons. Each sheath, if ‘unwrapped’, has a cytoplasm-filled space at its perimeter. Transmission electron microscopy reveals that this space contains microtubules and organelles; however, whether these are developmental remnants or serve a specific function remains unknown. Live imaging of myelinating oligodendrocytes in mice showed microtubule-dependent organelle transport within myelin sheath cytoplasmic spaces. Further, movement of myelin-located peroxisomes was modulated by neuronal electrical activity, in vitro and in vivo. Loss of oligodendroglial KIF21B and/or CNP in vivo led to the apparent stasis of myelin organelles and secondary axon pathology. We, thus, propose the acronym TRAM (transport route across myelin), defining the continuous cytoplasmic network in oligodendrocytes and myelin. This system, comprising the inner and outer tongues and paranodal loops, spans compact myelin and enables transport of metabolites and organelles between the oligodendrocyte soma and the periaxonal space.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer in oligodendrocytes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月31日

查看全文
  • Katie J. Chapple,
  • Tabitha R. F. Green,
  • Kristen H. Schuster,
  • Sarah Wirth,
  • Yi-Hsin Chen,
  • Ulrike C. Gerwig,
  • Marie Louise Aicher,
  • Yeonsu Kim,
  • Lina Komarek,
  • Angus Brown,
  • Colin L. Crawford,
  • Rebecca Sherrard Smith,
  • Jeffrey Y. Lee,
  • Lauren E. Black,
  • Luis Pardo,
  • Rebecca E. McHugh,
  • Celia M. Kassmann,
  • Wiebke Möbius,
  • Hauke B. Werner,
  • Ilan Davis,
  • Matthias Kneussel,
  • Ethan G. Hughes,
  • Euan R. Brown,
  • Sandra Goebbels,
  • Klaus-Armin Nave,
  • Julia M. Edgar

摘要

Myelin sheaths comprise compacted layers of membrane wrapped around axons. Each sheath, if ‘unwrapped’, has a cytoplasm-filled space at its perimeter. Transmission electron microscopy reveals that this space contains microtubules and organelles; however, whether these are developmental remnants or serve a specific function remains unknown. Live imaging of myelinating oligodendrocytes in mice showed microtubule-dependent organelle transport within myelin sheath cytoplasmic spaces. Further, movement of myelin-located peroxisomes was modulated by neuronal electrical activity, in vitro and in vivo. Loss of oligodendroglial KIF21B and/or CNP in vivo led to the apparent stasis of myelin organelles and secondary axon pathology. We, thus, propose the acronym TRAM (transport route across myelin), defining the continuous cytoplasmic network in oligodendrocytes and myelin. This system, comprising the inner and outer tongues and paranodal loops, spans compact myelin and enables transport of metabolites and organelles between the oligodendrocyte soma and the periaxonal space.