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<p>Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting. Here we investigated whether venous blood flow may play a role in controlling brain pressure. Using magnetic resonance imaging in patients with IIH and healthy controls, we identified that dural venous stenoses in IIH were associated with alterations of the perivenous fluid pattern and brain edema. We developed a mouse model of jugular vein ligation (JVL), which developed transient intracerebral hypertension, brain edema and impaired brain clearance, along with defective meningeal lymphatic vessels (MLVs). MLV depletion increased intracerebral pressure in control and JVL mice, but only MLV-deficient ligated mice failed to restore brain fluid clearance. These findings implicate MLVs in the control of intracerebral pressure and establish the dural venous sinuses as critical platforms where venous flow directs MLVs to ensure brain fluid clearance.</p>

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Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月22日

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  • Marie-Renee El Kamouh,
  • Myriam Spajer,
  • Ruchith Singhabahu,
  • Anne-Laure Joly Marolany,
  • Kurt A. Sailor,
  • Laura Mouton,
  • Diana Doukhi,
  • Sunil Koundal,
  • Tanner Metcalfe,
  • Dominique Langui,
  • Abel Grine,
  • Kevin Boyé,
  • Felipe Saceanu Leser,
  • Justus Ninnemann,
  • Joshua Gottschalk,
  • Cyrus Sadeghi,
  • Han Xu,
  • Ligia Simoes Braga Boisserand,
  • David Akbar,
  • Jerome Van Wassenhove,
  • Anthony Ruze,
  • Amelle Nasri,
  • Marie-Charlotte Bourrienne,
  • Elora Buscher,
  • Young-Kwon Hong,
  • Mikael Mazighi,
  • Pierre-Marie Lledo,
  • Helene Benveniste,
  • Mathieu Santin,
  • Anne Eichmann,
  • Stéphane Lehericy,
  • Jean-Léon Thomas,
  • Stéphanie Lenck

摘要

Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting. Here we investigated whether venous blood flow may play a role in controlling brain pressure. Using magnetic resonance imaging in patients with IIH and healthy controls, we identified that dural venous stenoses in IIH were associated with alterations of the perivenous fluid pattern and brain edema. We developed a mouse model of jugular vein ligation (JVL), which developed transient intracerebral hypertension, brain edema and impaired brain clearance, along with defective meningeal lymphatic vessels (MLVs). MLV depletion increased intracerebral pressure in control and JVL mice, but only MLV-deficient ligated mice failed to restore brain fluid clearance. These findings implicate MLVs in the control of intracerebral pressure and establish the dural venous sinuses as critical platforms where venous flow directs MLVs to ensure brain fluid clearance.