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<p>Socioeconomic status (SES) is a time-varying multidimensional construct with ill-defined dimension-specific and age-specific effects on brain and behavior. We investigated these effects in 4,228 young adults. From 16 socioeconomic indicators, assessed for early (0–10 years) and late (&gt;10 years) stages, we constructed family, provincial, family adverse and neighborhood adverse socioeconomic dimensions. Generally, family SES was associated with brain structure and connectivity along with cognitive function, whereas family adverse and neighborhood adverse SES were associated with personality and emotion. Most associations were observed for both early and late-stage SES; however, adjusting for the effect of early stage SES revealed late-stage-specific SES effects. Changes in SES were associated with personality and cognitive function. Cerebellar and medial frontal volumes and functional connectivity within the left frontoparietal network mediated the associations between family SES and memory and openness. These results inform both more precise interventions for reducing the consequences of adverse SES and experimental designs for excluding confounding socioeconomic effects on human health.</p>

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Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

  • 期刊论文

  • 发表日期：

    2025年2月24日

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  • Qiang Xu,
  • Su Lui,
  • Yuan Ji,
  • Jingliang Cheng,
  • Long Jiang Zhang,
  • Bing Zhang,
  • Wenzhen Zhu,
  • Zuojun Geng,
  • Guangbin Cui,
  • Quan Zhang,
  • Weihua Liao,
  • Yongqiang Yu,
  • Hui Zhang,
  • Bo Gao,
  • Xiaojun Xu,
  • Tong Han,
  • Zhenwei Yao,
  • Wen Qin,
  • Feng Liu,
  • Meng Liang,
  • Jilian Fu,
  • Jiayuan Xu,
  • Peng Zhang,
  • Wei Li,
  • Dapeng Shi,
  • Caihong Wang,
  • Jia-Hong Gao,
  • Zhihan Yan,
  • Feng Chen,
  • Jiance Li,
  • Jing Zhang,
  • Dawei Wang,
  • Wen Shen,
  • Yanwei Miao,
  • Junfang Xian,
  • Meiyun Wang,
  • Zhaoxiang Ye,
  • Xiaochu Zhang,
  • Xi-Nian Zuo,
  • Kai Xu,
  • Shijun Qiu,
  • Chunshui Yu,
  • Chunshui Yu,
  • Quan Zhang,
  • Junping Wang,
  • Xue Zhang,
  • Xinjun Suo,
  • Congcong Yuan,
  • Hui Xue,
  • Tianying Gao,
  • Junpeng Liu,
  • Yanjun Li,
  • Xi Guo,
  • Lixue Xu,
  • Jiajia Zhu,
  • Huaigui Liu,
  • Fangshi Zhao,
  • Jie Sun,
  • Yongjie Xu,
  • Huanhuan Cai,
  • Jie Tang,
  • Yaodan Zhang,
  • Yongqin Xiong,
  • Xianting Sun,
  • Nannan Pan,
  • Jiayang Yang,
  • Nana Liu,
  • Ya Wen,
  • Dan Zhu,
  • Bingjie Wu,
  • Wenshuang Zhu,
  • Qingqing Diao,
  • Yujuan Cao,
  • Bingbing Yang,
  • Lining Guo,
  • Yingying Xie,
  • Jiahui Lin,
  • Zhimin Li,
  • Yan Zhang,
  • Kaizhong Xue,
  • Zirui Wang,
  • Junlin Shen,
  • Meng Liang,
  • Xuejun Zhang,
  • Hao Ding,
  • Qian Su,
  • Mulin Jun Li,
  • Shijie Zhang,
  • Lun Ma,
  • Yan Bai,
  • Min Guan,
  • Wei Wei,
  • Peifang Miao,
  • Fuhong Duan,
  • Yafei Guo,
  • Weijian Wang,
  • Lijuan Zheng,
  • Li Lin,
  • Yunfei Wang,
  • Han Zhang,
  • Xinyuan Zhang,
  • Zhao Qing,
  • Sichu Wu,
  • Junxia Wang,
  • Yi Sun,
  • Yang He,
  • Xi-Nian Zuo,
  • Zhe Zhang,
  • Yin-Shan Wang,
  • Quan Zhou,
  • Tian Tian,
  • Yi Liang,
  • Yujie Liu,
  • Hui Zeng,
  • Jingxian Chen,
  • Haitao Ge,
  • Peng Xu,
  • Cailuan Lu,
  • Chen Wu,
  • Xiaoying Yang,
  • Yuzhao Wang,
  • Yankai Wu,
  • Xuran Feng,
  • Ling Li,
  • Duo Gao,
  • Rujing Zha,
  • Ying Li,
  • Lizhuang Yang,
  • Ying Chen,
  • Ling Zuo,
  • Jianqiao Ge,
  • Guoyuan Yang,
  • Wen Wang,
  • Linfeng Yan,
  • Yang Yang,
  • Jin Zhang,
  • Qian Wang,
  • Xiaoxia Qu,
  • Ying Wang,
  • Fei Yuan,
  • Li Hu,
  • Jizhen Li,
  • Weiwei Wang,
  • Yujing Zhou,
  • Miaomiao Long,
  • Lihua Liu,
  • Xiaohu Li,
  • Xiaoshu Li,
  • Yunjun Yang,
  • Nengzhi Xia,
  • Weihua Liao,
  • Shuai Yang,
  • Youming Zhang,
  • Jing Zhang,
  • Guangyao Liu,
  • Laiyang Ma,
  • Xiaochun Wang,
  • Ying Lei,
  • Bo Gao,
  • Gang Zhang,
  • Kang Yuan,
  • Jingjing Xu,
  • Xiaojun Guan,
  • Yuankai Lin,
  • Hui Juan Chen,
  • Yuchuan Fu,
  • Yi Lu,
  • Jun Guo,
  • Hao Lu,
  • Yue Wu

摘要

Socioeconomic status (SES) is a time-varying multidimensional construct with ill-defined dimension-specific and age-specific effects on brain and behavior. We investigated these effects in 4,228 young adults. From 16 socioeconomic indicators, assessed for early (0–10 years) and late (>10 years) stages, we constructed family, provincial, family adverse and neighborhood adverse socioeconomic dimensions. Generally, family SES was associated with brain structure and connectivity along with cognitive function, whereas family adverse and neighborhood adverse SES were associated with personality and emotion. Most associations were observed for both early and late-stage SES; however, adjusting for the effect of early stage SES revealed late-stage-specific SES effects. Changes in SES were associated with personality and cognitive function. Cerebellar and medial frontal volumes and functional connectivity within the left frontoparietal network mediated the associations between family SES and memory and openness. These results inform both more precise interventions for reducing the consequences of adverse SES and experimental designs for excluding confounding socioeconomic effects on human health.