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<p>Functional magnetic resonance imaging (fMRI) allows noninvasive measurement of neural activity with high spatial resolution. However, fMRI data are affected by noise. Here we introduce and evaluate a denoising method (DeepCor) that utilizes deep generative models to disentangle and remove noise. The method is applicable to data from single participants. DeepCor outperforms other state-of-the-art denoising approaches on a variety of simulated datasets. In real fMRI data, DeepCor enhances BOLD signal responses to face stimuli, outperforming CompCor by 215%.</p>

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DeepCor: denoising fMRI data with contrastive autoencoders

  • 期刊论文

  • 发表日期：

    2025年11月28日

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  • Yu Zhu,
  • Aidas Aglinskas,
  • Stefano Anzellotti

摘要

Functional magnetic resonance imaging (fMRI) allows noninvasive measurement of neural activity with high spatial resolution. However, fMRI data are affected by noise. Here we introduce and evaluate a denoising method (DeepCor) that utilizes deep generative models to disentangle and remove noise. The method is applicable to data from single participants. DeepCor outperforms other state-of-the-art denoising approaches on a variety of simulated datasets. In real fMRI data, DeepCor enhances BOLD signal responses to face stimuli, outperforming CompCor by 215%.