Scholarlink

<p>Tuberculosis (TB) remains a global health issue and leading cause of death. Understanding the immune response to <i>Mycobacterium tuberculosis</i> infection is critical to advance TB control. Although immune factors involved in protection against TB have long been identified, these cannot predict the efficacy of TB vaccines, nor which individuals will control the infection or progress to active TB disease. This is especially challenging given the complexity of <i>M. tuberculosis</i> infection states and the breadth of TB disease severities, which is increasingly apparent from basic, clinical and translational research. Here, we discuss the evolving spectrum of <i>M. tuberculosis</i> infection outcomes and TB disease, how the host immune response determines and unfolds across this spectrum and how the natural diversity of <i>M. tuberculosis</i> contributes to this complexity. Integration of these new concepts with fast-evolving systems immunology approaches holds great potential to inform the design of novel strategies to control TB.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The host immune response to Mycobacterium tuberculosis determining protection or disease progression

  • 期刊论文

  • 发表日期：

    2026年5月18日

查看全文
  • Margarida Saraiva,
  • William J. Branchett,
  • Jyothi Rengarajan,
  • Anne O’Garra

摘要

Tuberculosis (TB) remains a global health issue and leading cause of death. Understanding the immune response to Mycobacterium tuberculosis infection is critical to advance TB control. Although immune factors involved in protection against TB have long been identified, these cannot predict the efficacy of TB vaccines, nor which individuals will control the infection or progress to active TB disease. This is especially challenging given the complexity of M. tuberculosis infection states and the breadth of TB disease severities, which is increasingly apparent from basic, clinical and translational research. Here, we discuss the evolving spectrum of M. tuberculosis infection outcomes and TB disease, how the host immune response determines and unfolds across this spectrum and how the natural diversity of M. tuberculosis contributes to this complexity. Integration of these new concepts with fast-evolving systems immunology approaches holds great potential to inform the design of novel strategies to control TB.