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<p>Eosinophils are multifunctional granulocytes involved in immune regulation, metabolism and tissue repair; however, the extent of their heterogeneity across tissues and the principles governing their specialization are not well defined. Here, we present a single-cell transcriptomic and proteomic atlas of mouse eosinophils spanning immune, barrier and metabolic sites. By integrating transcriptional profiling, high-dimensional surface proteomics and in vivo fate mapping, we show that eosinophil identity is shaped by both tissue-derived cues and the duration of local residency. Long-lived eosinophils in the small intestine diversify into transcriptionally and phenotypically distinct subsets, whereas short-lived and intermediate-lived populations in the lungs and colon, respectively, remain comparatively uniform. We identify trajectory-associated surface markers that stratify eosinophil maturation from bone-marrow progenitors to long-term tissue-resident subsets. This atlas establishes a unified framework in which tissue-specific residency time drives eosinophil maturation and diversification, providing a molecular toolkit for resolving eosinophil states in health and disease.</p>

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Temporal and spatial atlas of eosinophil specialization across tissues

  • 期刊论文

  • 发表日期：

    2026年1月9日

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  • Yanan Hu,
  • Lianfu Wu,
  • Sihao Qu,
  • Wan Ting Kong,
  • Xiaotong Yu,
  • Jiaqian Xu,
  • Ziyi Xu,
  • Jialing He,
  • Chong Wang,
  • Zhaoyuan Liu,
  • Liming Lu,
  • Lai Guan Ng,
  • Camille Blériot,
  • Bing Su,
  • Florent Ginhoux,
  • Ziyi Li,
  • Svetoslav Chakarov

摘要

Eosinophils are multifunctional granulocytes involved in immune regulation, metabolism and tissue repair; however, the extent of their heterogeneity across tissues and the principles governing their specialization are not well defined. Here, we present a single-cell transcriptomic and proteomic atlas of mouse eosinophils spanning immune, barrier and metabolic sites. By integrating transcriptional profiling, high-dimensional surface proteomics and in vivo fate mapping, we show that eosinophil identity is shaped by both tissue-derived cues and the duration of local residency. Long-lived eosinophils in the small intestine diversify into transcriptionally and phenotypically distinct subsets, whereas short-lived and intermediate-lived populations in the lungs and colon, respectively, remain comparatively uniform. We identify trajectory-associated surface markers that stratify eosinophil maturation from bone-marrow progenitors to long-term tissue-resident subsets. This atlas establishes a unified framework in which tissue-specific residency time drives eosinophil maturation and diversification, providing a molecular toolkit for resolving eosinophil states in health and disease.